Signals, synapses, and synthesis: how new proteins control plasticity.

Details

Serval ID
serval:BIB_1139D914334B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Signals, synapses, and synthesis: how new proteins control plasticity.
Journal
Frontiers in neural circuits
Author(s)
Zukin R.S., Richter J.D., Bagni C.
ISSN
1662-5110 (Electronic)
ISSN-L
1662-5110
Publication state
Published
Issued date
2009
Volume
3
Pages
14
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Localization of mRNAs to dendrites and local protein synthesis afford spatial and temporal regulation of gene expression and endow synapses with the capacity to autonomously alter their structure and function. Emerging evidence indicates that RNA binding proteins, ribosomes, translation factors and mRNAs encoding proteins critical to synaptic structure and function localize to neuronal processes. RNAs are transported into dendrites in a translationally quiescent state where they are activated by synaptic stimuli. Two RNA binding proteins that regulate dendritic RNA delivery and translational repression are cytoplasmic polyadenylation element binding protein and fragile X mental retardation protein (FMRP). The fragile X syndrome (FXS) is the most common known genetic cause of autism and is characterized by the loss of FMRP. Hallmark features of the FXS include dysregulation of spine morphogenesis and exaggerated metabotropic glutamate receptor-dependent long term depression, a cellular substrate of learning and memory. Current research focuses on mechanisms whereby mRNAs are transported in a translationally repressed state from soma to distal process and are activated at synaptic sites in response to synaptic signals.

Keywords
Cpeb, Fmrp, cytoplasmic polyadenylation, fragile X syndrome, synaptic plasticity, synaptic signaling, translational control
Pubmed
Open Access
Yes
Create date
06/03/2017 17:23
Last modification date
20/08/2019 12:38
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