Phyllodes tumor of the breast.

Details

Serval ID
serval:BIB_11319121633A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Phyllodes tumor of the breast.
Journal
International Journal of Radiation Oncology, Biology, Physics
Author(s)
Belkacémi Y., Bousquet G., Marsiglia H., Ray-Coquard I., Magné N., Malard Y., Lacroix M., Gutierrez C., Senkus E., Christie D., Drumea K., Lagneau E., Kadish S.P., Scandolaro L., Azria D., Ozsahin M.
ISSN
0360-3016
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
70
Number
2
Pages
492-500
Language
english
Notes
Journal article --- Old month value: Oct 9
Abstract
PURPOSE: To better identify prognostic factors for local control and survival, as well as the role of different therapeutic options, for phyllodes tumors, a rare fibroepithelial neoplasm of the breast. METHODS AND MATERIALS: Data from 443 women treated between 1971 and 2003 were collected from the Rare Cancer Network. The median age was 40 years (range, 12-87 years). Tumors were benign in 284 cases (64%), borderline in 80 cases (18%), and malignant in 79 cases (18%). Surgery consisted of breast-conserving surgery (BCS) in 377 cases (85%) and total mastectomy (TM) in 66 cases (15%). Thirty-nine patients (9%) received adjuvant radiotherapy (RT). RESULTS: After a median follow-up of 106 months, local recurrence (LR) and distant metastases rates were 19% and 3.4%, respectively. In the malignant and borderline group (n = 159), RT significantly decreased LR (p = 0.02), and TM had better results than BCS (p = 0.0019). Multivariate analysis revealed benign histology, negative margins, and no residual disease (no RD) after initial treatment and RT delivery as independent favorable prognostic factors for local control; benign histology and low number of mitosis for disease-free survival; and pathologic tumor size < or = 3 cm and no tumor necrosis for overall survival. In the malignant and borderline subgroup multivariate analysis TM was the only favorable independent prognostic factor for disease-free survival. CONCLUSIONS: This study showed that phyllodes tumor patients with no RD after treatment have better local control. Benign tumors have a good prognosis after surgery alone. In borderline and malignant tumors, TM had better results than BCS. Thus, in these forms adjuvant RT should be considered according to histologic criteria.
Keywords
Adolescent, Adult, Aged, Aged, 80 and over, Analysis of Variance, Breast Neoplasms/pathology, Breast Neoplasms/radiotherapy, Child, Female, Follow-Up Studies, Humans, Mastectomy, Mastectomy, Segmental, Middle Aged, Neoplasm Recurrence, Local, Phyllodes Tumor/pathology, Phyllodes Tumor/radiotherapy, Prognosis, Radiotherapy, Adjuvant, Survival Rate
Pubmed
Web of science
Create date
24/01/2008 17:16
Last modification date
20/08/2019 12:38
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