A Bibliometric Review of the Keap1/Nrf2 Pathway and its Related Antioxidant Compounds.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_11053F010468
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
A Bibliometric Review of the Keap1/Nrf2 Pathway and its Related Antioxidant Compounds.
Journal
Antioxidants
Author(s)
Paunkov A., Chartoumpekis D.V., Ziros P.G., Sykiotis G.P.
ISSN
2076-3921 (Print)
ISSN-L
2076-3921
Publication state
Published
Issued date
01/09/2019
Peer-reviewed
Oui
Volume
8
Number
9
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Nrf2 is a master transcriptional regulator of antioxidant and cytoprotective pathways. Currently in its third decade, research on Nrf2 has expanded to encompass not only basic but also clinical studies. In the present bibliometric review, we employed the VOSviewer tool to describe the existing Nrf2 literature landscape. As of July 2019, 11,931 papers on Nrf2 were listed in the "Web of Science" database, with more than 1000 new papers published each year. As expected, terms related to oxidative stress and antioxidant molecules occur very often in the Nrf2 literature throughout the years. Interestingly, there is also a gradual increase in the occurrence of terms related to diseases or to natural compounds, the most prominent being sulforaphane, curcumin, and resveratrol that modulate the Nrf2 pathway. Going beyond molecular biology/biochemistry and related fields, Nrf2 research has begun to spread into more clinical areas like endocrinology/metabolism, cardiology, and nephrology, likely reflecting an increased interest in clinical applications of Nrf2 pathway activators. China has become the most prolific producer of Nrf2 papers the last five years followed by the USA and Japan, a reverse pattern compared to the past. In conclusion, Nrf2 is the subject of a globally active research field that keeps growing and extends from bench to bedside.
Keywords
Keap1, Nrf2, antioxidant, bibliography, cytoprotection, natural product, sulforaphane
Pubmed
Web of science
Open Access
Yes
Funding(s)
SNF/Programs/31003A_182105 SNF/Programs/C150045-174626 SNF/Programs/IZCOZ0-177070 OTHER//wiss Society for Endocrinology-Diabetology, 2014 Young Independent Investigator Award FOUNDATION_LEENAARDS//2016 Fellowship for Academic Promotion in Clinical Medicine OTHER//Union Européenne des Médecins Spécialistes (UEMS) Section of Endocrinology, 3E-Exchange in Endocrinology Expertise Fellowship
Create date
13/09/2019 18:21
Last modification date
06/03/2020 7:20
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