Monographies on drugs, which are frequently analysed in the course of Therapeutic Drug Monitoring

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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_110251023D43
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Monographies on drugs, which are frequently analysed in the course of Therapeutic Drug Monitoring
Journal
LaboratoriumsMedizin = Journal of Laboratory Medicine
Author(s)
Rentsch K., Fathi M., Grignaschi N., Magnin J.L., Printzen G., Thormann W., Wenk M, Werner D.
ISSN
0342-3026
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
29
Number
4
Pages
287-297
Language
english
Abstract
In 1995 the working group "Drug Monitoring" of the Swiss Society of Clinical Chemistry (SSCC) has already published a printed version of drug monographs, which are now newly compiled and presented in a standardised manner. The aim of these monographs is to give an overview on the most important informations that are necessary in order to request a drug analysis or is helpful to interpret the results. Therefore, the targeted audience are laboratory health professionals or the receivers of the reports.
There is information provided on the indication for therapeutic drug monitoring, protein binding, metabolic pathways and enzymes involved, elimination half life time and elimination routes as well as information on therapeutic or toxic concentrations.
Because preanalytical considerations are of particular importance for therapeutic drug monitoring, there is also information given at which time the determination of the drug concentration is reasonable and when steady-state concentrations are reached after changing the dose. Furthermore, the stability of the drug and its metabolite(s), respectively, after blood sampling is described.
For readers with a specific interest, references to important publications are given.
The number of the monographs will be continuously enlarged. The updated files are presented on the homepage of the SSCC (www.sscc.ch).
Open Access
Yes
Create date
25/02/2009 15:07
Last modification date
01/10/2019 6:16
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