Cumulative influence of organ dysfunctions and septic state on mortality of critically ill children

Details

Serval ID
serval:BIB_10BA39CC569B
Type
Article: article from journal or magazin.
Collection
Publications
Title
Cumulative influence of organ dysfunctions and septic state on mortality of critically ill children
Journal
Am J Respir Crit Care Med
Author(s)
Leclerc F., Leteurtre S., Duhamel A., Grandbastien B., Proulx F., Martinot A., Gauvin F., Hubert P., Lacroix J.
Publication state
Published
Issued date
02/2005
Volume
171
Number
4
Pages
348-53
Language
english
Abstract
The interaction between sepsis and multiple organ dysfunction syndrome is poorly defined in children. We analyzed by Cox regression models the cumulative influence of organ dysfunctions, using the pediatric logistic organ dysfunction (PELOD) score, and septic state (systemic inflammatory response syndrome or sepsis, severe sepsis, and septic shock) on mortality of critically ill children. We included 593 children (mortality rate: 8.6%) from three pediatric intensive care units; 514 patients had at least a systemic inflammatory response syndrome and 269 had two or more organ dysfunctions. Hazard ratio of death significantly increased with the severity of organ dysfunction, as estimated by the PELOD score, and the worst diagnostic category of septic state. Each increase of one unit in the PELOD score multiplied the hazard ratio by 1.096 (p < 0.0001); hazard ratio of diagnostic category was 9.039 (p = 0.031) for systemic inflammatory response syndrome or sepsis, 18.797 (p = 0.007) for severe sepsis and 32.572 (p < 0.001) for septic shock. Cumulative hazard ratio of death = (hazard ratio of PELOD score) x (hazard ratio of diagnostic category). We conclude that there is a cumulative accrual of the risk of death both with an increasing severity of organ dysfunction and an increasing severity of the diagnostic category of septic state.
Keywords
*Hospital Mortality, Child, Child, Preschool, Comorbidity, Critical Illness/*mortality, Female, France/epidemiology, Humans, Infant, Intensive Care Units, Pediatric/*statistics & numerical data, Length of Stay/statistics & numerical data, Male, Multiple Organ Failure/*epidemiology/*mortality, Outcome Assessment (Health Care)/*statistics & numerical data, Proportional Hazards Models, Prospective Studies, Sepsis/*epidemiology/*mortality, Severity of Illness Index, Time Factors
Create date
18/07/2019 12:48
Last modification date
21/08/2019 5:33
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