Mean platelet volume in the early phase of acute ischemic stroke is not associated with severity or functional outcome.

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State: Public
Version: author
Serval ID
serval:BIB_10B6C0A24740
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Mean platelet volume in the early phase of acute ischemic stroke is not associated with severity or functional outcome.
Journal
Cerebrovascular Diseases
Author(s)
Ntaios George, Gurer Ozgur, Faouzi Mohamed, Aubert Carole, Michel Patrik
ISSN
1421-9786 [electronic]
ISSN-L
1015-9770 [linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
29
Number
5
Pages
484-489
Language
english
Abstract
Background: Previous studies reported an increase of mean platelet volume (MPV) in patients with acute ischemic stroke. However, its correlation with stroke severity has not been investigated. Moreover, studies on the association of MPV with functional outcome yielded inconsistent results. Methods: We included all consecutive ischemic stroke patients admitted to CHUV (Centre Hospitalier Universitaire Vaudois) Neurology Service within 24 h after stroke onset who had MPV measured on admission. The association of MPV with stroke severity (NIHSS score at admission and at 24 h) and outcome (Rankin Scale score at 3 and 12 months) was analyzed in univariate analysis. The chi(2) test was performed to compare the frequency of minor strokes (NIHSS score </=4) and good functional outcome (Rankin Scale score </=2) across MPV quartiles. The ANOVA test was used to compare MPV between stroke subtypes according to the TOAST classification. Student's two-tailed unpaired t test was performed to compare MPV between lacunar and nonlacunar strokes. MPV was generated at admission by the Sysmex XE-2100 automated cell counter (Sysmex Corporation, Kobe, Japan) from EDTA blood samples. Results: There was no significant difference in the frequency of minor strokes (p = 0.46) and good functional outcome (p = 0.06) across MPV quartiles. MPV was not associated with stroke severity or outcome in univariate analysis. There was no significant difference in MPV between stroke subtypes according to the TOAST classification (p = 0.173) or between lacunar and nonlacunar strokes (10.50 +/- 0.91 vs. 10.40 +/- 0.81 fl, p = 0.322). Conclusions: MPV, assessed within 24 h after ischemic stroke onset, is not associated with stroke severity or functional outcome.
Keywords
Aged , Aged, 80 and over , Blood Platelets/pathology* , Data Interpretation, Statistical , Female , Humans , Male , Middle Aged , Platelet Count , Prognosis , Retrospective Studies , Severity of Illness Index* , Stroke/blood* , Stroke/diagnosis
Pubmed
Web of science
Create date
22/03/2010 8:52
Last modification date
07/01/2020 7:08
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