Patterns of carbon-bound exogenous compounds in lung cancer patients and association with disease pathophysiology.

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State: Public
Version: Author's accepted manuscript
License: Not specified
Serval ID
serval:BIB_10B46795FCEE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Patterns of carbon-bound exogenous compounds in lung cancer patients and association with disease pathophysiology.
Journal
Cancer research
Author(s)
Kunzke T., Prade V.M., Buck A., Sun N., Feuchtinger A., Matzka M., Fernandez I.E., Wuyts W., Ackermann M., Jonigk D., Aichler M., Schmid R.A., Eickelberg O., Berezowska S., Walch A.
ISSN
1538-7445 (Electronic)
ISSN-L
0008-5472
Publication state
Published
Issued date
19/10/2021
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Asymptomatic anthracosis is the accumulation of black carbon particles in adult human lungs. It is a common occurrence, but the pathophysiological significance of anthracosis is debatable. Using in situ high mass resolution matrix-assisted laser desorption/ionization (MALDI) fourier-transform ion cyclotron resonance (FT-ICR) mass spectrometry imaging analysis, we discovered noxious carbon-bound exogenous compounds, such as polycyclic aromatic hydrocarbons (PAHs), tobacco-specific nitrosamines, or aromatic amines, in a series of 330 lung cancer patients in highly variable and unique patterns. The characteristic nature of carbon-bound exogenous compound had a strong association with patient outcome, tumor progression, the tumor immune microenvironment, PD-L1 expression, and DNA damage. Spatial correlation network analyses revealed substantial differences in the metabolome of tumor cells compared to tumor stroma depending on carbon-bound exogenous compounds. Overall, the bioactive pool of exogenous compounds is associated with several changes in lung cancer pathophysiology and correlates with patient outcome. Given the high prevalence of anthracosis in the lungs of adult humans, future work should investigate the role of carbon-bound exogenous compounds in lung carcinogenesis and lung cancer therapy.
Pubmed
Create date
25/10/2021 8:19
Last modification date
11/11/2021 7:08
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