Resting state brain dynamics: Associations with childhood sexual abuse and major depressive disorder.
Details
State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_109F10B59BD2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Resting state brain dynamics: Associations with childhood sexual abuse and major depressive disorder.
Journal
NeuroImage. Clinical
ISSN
2213-1582 (Electronic)
ISSN-L
2213-1582
Publication state
Published
Issued date
2022
Peer-reviewed
Oui
Volume
36
Pages
103164
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Early life stress (ELS) and major depressive disorder (MDD) share neural network abnormalities. However, it is unclear how ELS and MDD may separately and/or jointly relate to brain networks, and whether neural differences exist between depressed individuals with vs without ELS. Moreover, prior work evaluated static versus dynamic network properties, a critical gap considering brain networks show changes in coordinated activity over time. Seventy-one unmedicated females with and without childhood sexual abuse (CSA) histories and/or MDD completed a resting state scan and a stress task in which cortisol and affective ratings were collected. Recurring functional network co-activation patterns (CAPs) were examined and time in CAP (number of times each CAP is expressed) and transition frequencies (transitioning between different CAPs) were computed. The effects of MDD and CSA on CAP metrics were examined and CAP metrics were correlated with depression and stress-related variables. Results showed that MDD, but not CSA, related to CAP metrics. Specifically, individuals with MDD (N = 35) relative to HCs (N = 36), spent more time in a posterior default mode (DMN)-frontoparietal network (FPN) CAP and transitioned more frequently between posterior DMN-FPN and prototypical DMN CAPs. Across groups, more time spent in a posterior DMN-FPN CAP and greater DMN-FPN and prototypical DMN CAP transition frequencies were linked to higher rumination. Imbalances between the DMN and the FPN appear central to MDD and might contribute to MDD-related cognitive dysfunction, including rumination. Unexpectedly, CSA did not modulate such dysfunctions, a finding that needs to be replicated by future studies with larger sample sizes.
Keywords
Female, Child, Humans, Depressive Disorder, Major, Neural Pathways, Magnetic Resonance Imaging/methods, Brain/diagnostic imaging, Brain Mapping/methods, Sex Offenses, Brain network dynamics, Co-activation pattern analysis, Depression, Early life stress, Resting state fMRI, Rumination
Pubmed
Web of science
Open Access
Yes
Create date
05/09/2022 8:55
Last modification date
09/08/2024 15:55