Tissue-specific segregation of CD1d-dependent and CD1d-independent NK T cells.

Details

Serval ID
serval:BIB_10526
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Tissue-specific segregation of CD1d-dependent and CD1d-independent NK T cells.
Journal
Journal of Immunology
Author(s)
Eberl G., Lees R., Smiley S.T., Taniguchi M., Grusby M.J., MacDonald H.R.
ISSN
0022-1767
Publication state
Published
Issued date
1999
Peer-reviewed
Oui
Volume
162
Number
11
Pages
6410-6419
Language
english
Abstract
NKT cells, defined as T cells expressing the NK cell marker NK1.1, are involved in tumor rejection and regulation of autoimmunity via the production of cytokines. We show in this study that two types of NKT cells can be defined on the basis of their reactivity to the monomorphic MHC class I-like molecule CD1d. One type of NKT cell is positively selected by CD1d and expresses a biased TCR repertoire together with a phenotype found on activated T cells. A second type of NKT cell, in contrast, develops in the absence of CD1d, and expresses a diverse TCR repertoire and a phenotype found on naive T cells and NK cells. Importantly, the two types of NKT cells segregate in distinct tissues. Whereas thymus and liver contain primarily CD1d-dependent NKT cells, spleen and bone marrow are enriched in CD1d-independent NKT cells. Collectively, our data suggest that recognition of tissue-specific ligands by the TCR controls localization and activation of NKT cells.
Keywords
Animals, Antigens/biosynthesis, Antigens, CD1/physiology, Antigens, CD1d, Antigens, CD4/biosynthesis, Antigens, CD8/biosynthesis, Antigens, Differentiation, B-Lymphocyte/genetics, Antigens, Differentiation, T-Lymphocyte/biosynthesis, Antigens, Ly, Antigens, Surface, Biological Markers, Female, Genes, T-Cell Receptor alpha/immunology, Histocompatibility Antigens Class II/genetics, Killer Cells, Natural/immunology, Lectins, C-Type, Lymphocyte Activation/immunology, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Nude, NK Cell Lectin-Like Receptor Subfamily B, Organ Specificity/immunology, Protein Biosynthesis, Proteins, Receptors, Antigen, T-Cell, alpha-beta/biosynthesis, T-Lymphocyte Subsets/immunology, T-Lymphocyte Subsets/metabolism, Thymus Gland/immunology, Thymus Gland/metabolism
Pubmed
Web of science
Create date
19/11/2007 12:00
Last modification date
20/08/2019 12:37
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