Pulmonary Blood Volume Measured by Dual-Energy Computed Tomography Can Help Distinguish Patients With Pulmonary Hypertension.

Details

Serval ID
serval:BIB_1044942C0432
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Pulmonary Blood Volume Measured by Dual-Energy Computed Tomography Can Help Distinguish Patients With Pulmonary Hypertension.
Journal
Frontiers in cardiovascular medicine
Author(s)
Rezaei-Kalantari K., Samimi K., Zomorodian H., Bakhshandeh H., Jafari M., Farahmand A.M., Pourseyedian T., Sharifian M., Qanadli S.D.
ISSN
2297-055X (Print)
ISSN-L
2297-055X
Publication state
Published
Issued date
2022
Peer-reviewed
Oui
Volume
9
Pages
835655
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
To evaluate the correlation between whole lung enhancement (WLE) and pulmonary blood volume (PBV) obtained through dual energy computed tomography pulmonary angiography (DECTPA) and echocardiography-derived systolic pulmonary arterial pressure (SPAP).
Sixty-eight patients who underwent DECTPA were enrolled in the study after giving informed consent. A transthoracic echocardiography was performed for all the subjects within 48 h of their DECTPA study to measure SPAP. The correlation of the two DECTPA-derived parameters, WLE and PBV, with SPAP was assessed. In addition, the predictive strength of these parameters was compared with that of traditional computed tomography (CT) signs of pulmonary hypertension (PH).
The SPAP value showed a moderate correlation with main pulmonary artery (MPA) diameter (r = 0.48, P < 0.001), while having a weak correlation with WLE (r = -0.33, P = 0.007), PBV (r = -0.31, P = 0.01) and MPA/ascending aorta (MPA/AA) ratio (r = 0.26, P = 0.03). On regression analysis, MPA diameter (B ± SE: 1.8 ± 0.6, P = 0.004) and WLE (B ± SE: -0.5 ± 0.3, P = 0.042) had significant association with SPAP. In addition, SPAP ≥30 mmHg was related to the right to left ventricular diameter (RV/LV) ratio [OR (CI 95%): 24.39 (1.3-573.2), P = 0.04] and reversely associated with PBV [OR (CI 95%): 0.96 (0.93-0.98), P = 0.005]. Acquired cutoff value of 83% for PBV showed sensitivity and specificity of 73% to identify SPAP ≥30 mmHg [AUC (CI 95%):0.727 (0.588-0.866), P = 0.008].
Automated postprocessing calculation of iodine distribution analysis by DECTPA could be considered as an adjunctive tool to investigate for PH.
Keywords
dual energy computed tomography pulmonary angiography, pulmonary artery pressure, pulmonary blood volume, pulmonary hypertension, whole lung enhancement
Pubmed
Web of science
Open Access
Yes
Create date
02/08/2022 14:38
Last modification date
21/11/2023 8:11
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