Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human.

Details

Serval ID
serval:BIB_10358
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human.
Journal
Physiological Reviews
Author(s)
Widmann C., Gibson S., Jarpe M.B., Johnson G.L.
ISSN
0031-9333
Publication state
Published
Issued date
1999
Volume
79
Number
1
Pages
143-180
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Mitogen-activated protein kinases (MAPK) are serine-threonine protein kinases that are activated by diverse stimuli ranging from cytokines, growth factors, neurotransmitters, hormones, cellular stress, and cell adherence. Mitogen-activated protein kinases are expressed in all eukaryotic cells. The basic assembly of MAPK pathways is a three-component module conserved from yeast to humans. The MAPK module includes three kinases that establish a sequential activation pathway comprising a MAPK kinase kinase (MKKK), MAPK kinase (MKK), and MAPK. Currently, there have been 14 MKKK, 7 MKK, and 12 MAPK identified in mammalian cells. The mammalian MAPK can be subdivided into five families: MAPKerk1/2, MAPKp38, MAPKjnk, MAPKerk3/4, and MAPKerk5. Each MAPK family has distinct biological functions. In Saccharomyces cerevisiae, there are five MAPK pathways involved in mating, cell wall remodelling, nutrient deprivation, and responses to stress stimuli such as osmolarity changes. Component members of the yeast pathways have conserved counterparts in mammalian cells. The number of different MKKK in MAPK modules allows for the diversity of inputs capable of activating MAPK pathways. In this review, we define all known MAPK module kinases from yeast to humans, what is known about their regulation, defined MAPK substrates, and the function of MAPK in cell physiology.
Keywords
Animals, Calcium-Calmodulin-Dependent Protein Kinases/genetics, Calcium-Calmodulin-Dependent Protein Kinases/metabolism, Evolution, Molecular, Fungal Proteins/genetics, Fungal Proteins/metabolism, Humans, MAP Kinase Kinase Kinases, Mitogen-Activated Protein Kinase Kinases, Protein Kinases/genetics, Protein Kinases/metabolism, Protein-Serine-Threonine Kinases/genetics, Protein-Serine-Threonine Kinases/metabolism, Saccharomyces cerevisiae/enzymology, Saccharomyces cerevisiae/genetics
Pubmed
Web of science
Create date
19/11/2007 12:00
Last modification date
20/08/2019 12:37
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