Comprehensive molecular characterization of gastric adenocarcinoma.
Details
Serval ID
serval:BIB_1027D1F6C2C2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Comprehensive molecular characterization of gastric adenocarcinoma.
Journal
Nature
Working group(s)
Cancer Genome Atlas Research Network
Contributor(s)
Bass A.J., Thorsson V., Shmulevich I., Reynolds S.M., Miller M., Bernard B., Hinoue T., Laird P.W., Curtis C., Shen H., Weisenberger D.J., Schultz N., Shen R., Weinhold N., Kelsen D.P., Bowlby R., Chu A., Kasaian K., Mungall A.J., Robertson A.G., Sipahimalani P., Cherniack A.D., Getz G., Liu Y., Noble M.S., Pedamallu C., Sougnez C., Taylor-Weiner A., Akbani R., Lee J.S., Liu W., Mills G.B., Yang D., Zhang W., Pantazi A., Parfenov M., Gulley M., Piazuelo M.B., Schneider B.G., Kim J., Boussioutas A., Sheth M., Demchok J.A., Rabkin C.S., Willis J.E., Ng S., Garman K., Beer D.G., Pennathur A., Raphael B.J., Wu H.T., Odze R., Kim H.K., Bowen J., Leraas K.M., Lichtenberg T.M., Weaver S., McLellan M., Wiznerowicz M., Sakai R., Getz G., Sougnez C., Lawrence M.S., Cibulskis K., Lichtenstein L., Fisher S., Gabriel S.B., Lander E.S., Ding L., Niu B., Ally A., Balasundaram M., Birol I., Bowlby R., Brooks D., Butterfield Y.S., Carlsen R., Chu A., Chu J., Chuah E., Chun H.J., Clarke A., Dhalla N., Guin R., Holt R.A., Jones S.J., Kasaian K., Lee D., Li H.A., Lim E., Ma Y., Marra M.A., Mayo M., Moore R.A., Mungall A.J., Mungall K.L., Ming Nip K., Robertson A.G., Schein J.E., Sipahimalani P., Tam A., Thiessen N., Beroukhim R., Carter S.L., Cherniack A.D., Cho J., Cibulskis K., DiCara D., Frazer S., Fisher S., Gabriel S.B., Gehlenborg N., Heiman D.I., Jung J., Kim J., Lander E.S., Lawrence M.S., Lichtenstein L., Lin P., Meyerson M., Ojesina A.I., Sekhar Pedamallu C., Saksena G., Schumacher S.E., Sougnez C., Stojanov P., Tabak B., Taylor-Weiner A., Voet D., Rosenberg M., Zack T.I., Zhang H., Zou L., Protopopov A., Santoso N., Parfenov M., Lee S., Zhang J., Mahadeshwar H.S., Tang J., Ren X., Seth S., Yang L., Xu A.W., Song X., Pantazi A., Xi R., Bristow C.A., Hadjipanayis A., Seidman J., Chin L., Park P.J., Kucherlapati R., Akbani R., Ling S., Liu W., Rao A., Weinstein J.N., Kim S.B., Lee J.S., Lu Y., Mills G., Laird P.W., Hinoue T., Weisenberger D.J., Bootwalla M.S., Lai P.H., Shen H., Triche T., Van Den Berg D.J., Baylin S.B., Herman J.G., Getz G., Chin L., Liu Y., Murray B.A., Noble M.S., Askoy B.A., Ciriello G., Dresdner G., Gao J., Gross B., Jacobsen A., Lee W., Ramirez R., Sander C., Schultz N., Senbabaoglu Y., Sinha R., Sumer S.O., Sun Y., Weinhold N., Thorsson V., Bernard B., Iype L., Kramer R.W., Kreisberg R., Miller M., Reynolds S.M., Rovira H., Tasman N., Shmulevich I., Ng S., Haussler D., Stuart J.M., Akbani R., Ling S., Liu W., Rao A., Weinstein J.N., Verhaak R.G., Mills G.B., Leiserson M.D., Raphael B.J., Wu H.T., Taylor B.S., Black A.D., Bowen J., Carney J.A., Gastier-Foster J.M., Helsel C., Leraas K.M., Lichtenberg T.M., McAllister C., Ramirez N.C., Tabler T.R., Wise L., Zmuda E., Penny R., Crain D., Gardner J., Lau K., Curely E., Mallery D., Morris S., Paulauskis J., Shelton T., Shelton C., Sherman M., Benz C., Lee J.H., Fedosenko K., Manikhas G., Potapova O., Voronina O., Belyaev D., Dolzhansky O., Rathmell W.K., Brzezinski J., Ibbs M., Korski K., Kycler W., Laźniak R., Leporowska E., Mackiewicz A., Murawa D., Murawa P., Spychała A., Suchorska W.M., Tatka H., Teresiak M., Wiznerowicz M., Abdel-Misih R., Bennett J., Brown J., Iacocca M., Rabeno B., Kwon S.Y., Penny R., Gardner J., Kemkes A., Mallery D., Morris S., Shelton T., Shelton C., Curley E., Alexopoulou I., Engel J., Bartlett J., Albert M., Park D.Y., Dhir R., Luketich J., Landreneau R., Janjigian Y.Y., Kelsen D.P., Cho E., Ladanyi M., Tang L., McCall S.J., Park Y.S., Cheong J.H., Ajani J., Camargo M.C., Alonso S., Ayala B., Jensen M.A., Pihl T., Raman R., Walton J., Wan Y., Demchok J.A., Eley G., Mills Shaw K.R., Sheth M., Tarnuzzer R., Wang Z., Yang L., Zenklusen J.C., Davidsen T., Hutter C.M., Sofia H.J., Burton R., Chudamani S., Liu J.
ISSN
1476-4687 (Electronic)
ISSN-L
0028-0836
Publication state
Published
Issued date
11/09/2014
Peer-reviewed
Oui
Volume
513
Number
7517
Pages
202-209
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
Publication Status: ppublish
Publication Status: ppublish
Abstract
Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. Here we describe a comprehensive molecular evaluation of 295 primary gastric adenocarcinomas as part of The Cancer Genome Atlas (TCGA) project. We propose a molecular classification dividing gastric cancer into four subtypes: tumours positive for Epstein-Barr virus, which display recurrent PIK3CA mutations, extreme DNA hypermethylation, and amplification of JAK2, CD274 (also known as PD-L1) and PDCD1LG2 (also known as PD-L2); microsatellite unstable tumours, which show elevated mutation rates, including mutations of genes encoding targetable oncogenic signalling proteins; genomically stable tumours, which are enriched for the diffuse histological variant and mutations of RHOA or fusions involving RHO-family GTPase-activating proteins; and tumours with chromosomal instability, which show marked aneuploidy and focal amplification of receptor tyrosine kinases. Identification of these subtypes provides a roadmap for patient stratification and trials of targeted therapies.
Keywords
Adenocarcinoma/classification, Adenocarcinoma/genetics, Adenocarcinoma/virology, Female, Gene Expression Regulation, Neoplastic, Genome, Human/genetics, Herpesvirus 4, Human/genetics, Herpesvirus 4, Human/isolation & purification, Humans, Male, Mutation, Proteome, Stomach Neoplasms/classification, Stomach Neoplasms/genetics, Stomach Neoplasms/virology
Pubmed
Web of science
Open Access
Yes
Create date
13/11/2018 10:27
Last modification date
20/08/2019 13:36
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