Cold-inducible RNA-binding protein (CIRBP) adjusts clock-gene expression and REM-sleep recovery following sleep deprivation.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_100CC3FE7D22
Type
Article: article from journal or magazin.
Collection
Publications
Title
Cold-inducible RNA-binding protein (CIRBP) adjusts clock-gene expression and REM-sleep recovery following sleep deprivation.
Journal
eLife
Author(s)
Hoekstra M.M., Emmenegger Y., Hubbard J., Franken P.
ISSN
2050-084X (Electronic)
ISSN-L
2050-084X
Publication state
Published
Issued date
05/02/2019
Peer-reviewed
Oui
Volume
8
Pages
e43400
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Sleep depriving mice affects clock-gene expression, suggesting that these genes contribute to sleep homeostasis. The mechanisms linking extended wakefulness to clock-gene expression are, however, not well understood. We propose CIRBP to play a role because its rhythmic expression is i) sleep-wake driven and ii) necessary for high-amplitude clock-gene expression in vitro. We therefore expect Cirbp knock-out (KO) mice to exhibit attenuated sleep-deprivation-induced changes in clock-gene expression, and consequently to differ in their sleep homeostatic regulation. Lack of CIRBP indeed blunted the sleep-deprivation incurred changes in cortical expression of Nr1d1, whereas it amplified the changes in Per2 and Clock. Concerning sleep homeostasis, KO mice accrued only half the extra REM sleep wild-type (WT) littermates obtained during recovery. Unexpectedly, KO mice were more active during lights-off which was accompanied with faster theta oscillations compared to WT mice. Thus, CIRBP adjusts cortical clock-gene expression after sleep deprivation and expedites REM-sleep recovery.
Keywords
Animals, CLOCK Proteins/biosynthesis, Gene Expression, Gene Knockout Techniques, Mice, Inbred C57BL, Mice, Knockout, RNA-Binding Proteins/genetics, RNA-Binding Proteins/metabolism, Sleep Deprivation, Sleep, REM, REM sleep, circadian rhythm, clock genes, cortical temperature, locomotor activity, mouse, neuroscience, sleep
Pubmed
Web of science
Open Access
Yes
Create date
11/03/2019 15:51
Last modification date
05/04/2020 6:20
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