Clinical and biological determinants of kidney outcomes in a population-based cohort study

Details

Serval ID
serval:BIB_100057102FD2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Clinical and biological determinants of kidney outcomes in a population-based cohort study
Journal
Kidney and Blood Pressure Research
Author(s)
Guessous I., Ponte B., Marques-Vidal P., Paccaud F., Gaspoz J.M., Burnier M., Waeber G., Vollenweider P., Bochud M.
ISSN
1423-0143 (Electronic)
ISSN-L
1420-4096
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
39
Number
1
Pages
74-85
Language
english
Abstract
BACKGROUND/AIMS: Prospective studies on factors associated with adverse kidney outcomes in European general populations are scant. Also, few studies consider the potential confounding effect of baseline kidney function.
METHODS: We used baseline (2003-2006) and 5-year follow-up data of adults from the general population to evaluate the effect of baseline kidney function and proteinuria on the association of clinical, biological (e.g. uric acid, homocysteine, cytokines), and socioeconomic factors with change in kidney function, rapid decline in kidney function, and incidence of chronic kidney disease (CKD). Estimated glomerular filtration rate (eGFR) and urinary albuminuria-to-creatinine ratio (UACR) were collected. Kidney outcomes were modeled using multivariable regressions.
RESULTS: A total of 4,441 subjects were included in the analysis. Among participants without CKD at baseline, 11.4% presented rapid decline in eGFR and/or incident CKD. After adjustment for baseline eGFR and log UACR, only age (Odds Ratio; 1.25 [95%CI 1.18-1.33]), diabetes (OR 1.48 [1.03-2.13]), education (OR middle vs. high 1.51 [1.08-2.11]) and log ultrasensitive CRP (OR 1.16 [1.05-1.22]) were associated with rapid decline in eGFR or incident CKD. Baseline log UACR (OR 1.18 [1.06-1.32]) but not eGFR was associated with rapid decline in eGFR and/or incident CKD.
CONCLUSION: In addition to age and diabetes, education and CRP levels are associated with adverse kidney outcomes independently of baseline kidney function.
Pubmed
Web of science
Open Access
Yes
Create date
19/09/2014 7:03
Last modification date
20/08/2019 12:36
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