Usefulness of liver function tests in postmortem samples

Details

Ressource 1Download: Mémoire no 4335 M. Fumeaux.pdf (738.91 [Ko])
State: Public
Version: After imprimatur
License: Not specified
Serval ID
serval:BIB_0FF2CF3F5516
Type
A Master's thesis.
Publication sub-type
Master (thesis) (master)
Collection
Publications
Institution
Title
Usefulness of liver function tests in postmortem samples
Author(s)
FUMEAUX L.
Director(s)
PALMIERE C.
Institution details
Université de Lausanne, Faculté de biologie et médecine
Publication state
Accepted
Issued date
2017
Language
english
Number of pages
15
Abstract
Abstract
Liver function tests have been investigated in the forensic setting in several biological fluids collected at autopsy. Nevertheless, the results of these investigations have provided diverging information on postmortem stability of liver function markers and postmortem reliability of liver function assessment. The first aim of this study was to determine gamma-glutamyltransferase, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin, total proteins, and albumin in antemortem and postmortem serum samples in a series of cases that underwent forensic investigations and had both samples available. The second aim was to measure the same molecules in cerebrospinal fluid. Preliminary results indicated that femoral (and cardiac) blood postmortem serum concentrations of bilirubin, total proteins, and albumin, as well as femoral blood postmortem serum concentrations of gamma-glutamyltransferase, can be considered to reliably reflect antemortem serum concentrations, thus suggesting that postmortem values could be used as surrogates for antemortem levels. Conversely, alanine aminotransferase, alkaline phosphatase and bilirubin levels in cerebrospinal fluid stored in both preservative-free and sodium fluoride tubes are of no value to estimate their antemortem serum concentrations, irrespective of liver disease severity found at autopsy.
Keywords
Postmortem biochemistry, Autopsy, Liver function tests, Postmortem serum, Cerebrospinal fluid
Create date
06/09/2018 9:18
Last modification date
08/09/2020 6:08
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