Revisiting the diacylglycerol-induced insulin resistance hypothesis.

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Version: Author's accepted manuscript
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Serval ID
serval:BIB_0FD7860E7D7F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Revisiting the diacylglycerol-induced insulin resistance hypothesis.
Journal
Obesity Reviews
Author(s)
Amati F.
ISSN
1467-789X (Electronic)
ISSN-L
1467-7881
Publication state
Published
Issued date
12/2012
Peer-reviewed
Oui
Volume
13
Number
Suppl 2
Pages
40-50
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
Obesity is associated with skeletal muscle insulin resistance, which is a crucial step in the development of type 2 diabetes. Among the mechanisms by which obesity may lead to insulin resistance, lipotoxicity is one of the hypotheses being explored; others include inflammation or the oxidative stress hypotheses. This review focuses on the role of diacylglycerols (DAG), a family of lipid metabolites implicated in the pathogenesis of lipotoxicity and insulin resistance. While recent studies report contradictory results in humans with regard to the importance of DAG-induced insulin resistance in skeletal muscle, other current literature highlight a potential role for DAG as signalling molecules. This review will discuss possible hypotheses explaining these contradictory results and the need to explore further the role of DAG in human metabolism.
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / Careers / PZ00P3-126339
Create date
19/11/2012 18:31
Last modification date
20/01/2020 6:20
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