Implementing SARS-CoV-2 Rapid Antigen Testing in the Emergency Ward of a Swiss University Hospital: The INCREASE Study.

Details

Serval ID
serval:BIB_0FC767B1B433
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Implementing SARS-CoV-2 Rapid Antigen Testing in the Emergency Ward of a Swiss University Hospital: The INCREASE Study.
Journal
Microorganisms
Author(s)
Caruana G., Croxatto A., Kampouri E., Kritikos A., Opota O., Foerster M., Brouillet R., Senn L., Lienhard R., Egli A., Pantaleo G., Carron P.N., Greub G.
ISSN
2076-2607 (Print)
ISSN-L
2076-2607
Publication state
Published
Issued date
10/04/2021
Peer-reviewed
Oui
Volume
9
Number
4
Pages
798
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Following the Swiss Federal Office of Public Health (FOPH) authorization of the rapid antigen test (RAT), we implemented the use of the RAT in the emergency ward of our university hospital for patients' cohorting. RAT triaging in association with RT-PCR allowed us to promptly isolate positive patients and save resources. Among 532 patients, overall sensitivities were 48.3% for Exdia and 41.2% for Standard Q <sup>®</sup> , Panbio <sup>TM</sup> and BD Veritor™. All RATs exhibited specificity above 99%. Sensitivity increased to 74.6%, 66.2%, 66.2% and 64.8% for Exdia, Standard Q <sup>®</sup> , Panbio <sup>TM</sup> and BD Veritor™, respectively, for viral loads above 10 <sup>5</sup> copies/mL, to 100%, 97.8%, 96.6% and 95.6% for viral loads above 10 <sup>6</sup> copies/mL and 100% for viral loads above 10 <sup>7</sup> copies/mL. Sensitivity was significantly higher for patients with symptoms onset within four days (74.3%, 69.2%, 69.2% and 64%, respectively) versus patients with the evolution of symptoms longer than four days (36.8%, 21.1%, 21.1% and 23.7%, respectively). Among COVID-19 asymptomatic patients, sensitivity was 33%. All Immunoglobulin-A-positive patients resulted negative for RAT. The RAT might represent a useful resource in selected clinical settings as a complementary tool in RT-PCR for rapid patient triaging, but the lower sensitivity, especially in late presenters and COVID-19 asymptomatic subjects, must be taken into account.
Keywords
COVID-19 diagnostic testing, SARS-CoV-2, emergency ward, health plan implementation, nucleocapsid protein, rapid antigen test
Pubmed
Web of science
Open Access
Yes
Create date
07/05/2021 18:06
Last modification date
29/05/2021 6:32
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