Renal perfusion evaluation with contrast-enhanced ultrasonography.

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Serval ID
serval:BIB_0FBD29996D50
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Renal perfusion evaluation with contrast-enhanced ultrasonography.
Journal
Nephrology, Dialysis, Transplantation
Author(s)
Schneider A.G., Hofmann L., Wuerzner G., Glatz N., Maillard M., Meuwly J.Y., Eggimann P., Burnier M., Vogt B.
ISSN
1460-2385 (Electronic)
ISSN-L
0931-0509
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
27
Number
2
Pages
674-681
Language
english
Notes
Publication types: Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
Abstract
BACKGROUND: Contrast-enhanced ultrasonography (CEUS) is a novel imaging technique that is safe and applicable on the bedside. Recent developments seem to enable CEUS to quantify organ perfusion. We performed an exploratory study to determine the ability of CEUS to detect changes in renal perfusion and to correlate them with effective renal plasma flow.
METHODS: CEUS with destruction-refilling sequences was studied in 10 healthy subjects, at baseline and during infusion of angiotensin II (AngII) at low (1 ng/kg/min) and high dose (3 ng/kg/min) and 1 h after oral captopril (50 mg). Perfusion index (PI) was obtained and compared with the effective renal plasma flow (ERPF) obtained by parallel para-aminohippurate (PAH) clearance.
RESULTS: Median PI decreased from 188.6 (baseline) to 100.4 with low-dose AngII (-47%; P < 0.02) and to 66.1 with high-dose AngII (-65%; P < 0.01) but increased to 254.7 with captopril (+35%; P > 0.2). These changes parallelled those observed with ERPF, which changed from a median of 672.1 mL/min (baseline) to 572.3 (low-dose AngII, -15%, P < 0.05) and to 427.2 (high-dose AngII, -36%, P < 0.001) and finally 697.1 (captopril, +4%, P < 0.02).
CONCLUSIONS: This study demonstrates that CEUS is able to detect changes in human renal cortical microcirculation as induced by AngII infusion and/or captopril administration. The changes in perfusion indices parallel those in ERPF as obtained by PAH clearance.
Keywords
Adult, Angiotensin II/pharmacology, Captopril/pharmacology, Cohort Studies, Contrast Media/diagnostic use, Humans, Image Enhancement/methods, Kidney Cortex/blood supply, Kidney Cortex/drug effects, Male, Microcirculation/drug effects, Microcirculation/physiology, Observer Variation, Reference Values, Renal Circulation/drug effects, Renal Circulation/physiology, Renal Plasma Flow, Effective/drug effects, Sensitivity and Specificity, Ultrasonography, Doppler/methods, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
27/06/2011 17:58
Last modification date
25/09/2019 7:08
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