Morphological redifferentiation in a malignant astrocytic tumor after gamma knife radiosurgery.

Details

Serval ID
serval:BIB_0FB9F9FB3BAD
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Morphological redifferentiation in a malignant astrocytic tumor after gamma knife radiosurgery.
Journal
Journal of Neurosurgery
Author(s)
Szeifert G.T., Massager N., Brotchi J., Levivier M.
ISSN
0022-3085 (Print)
ISSN-L
0022-3085
Publication state
Published
Issued date
2002
Peer-reviewed
Oui
Volume
97
Number
5 Suppl.
Pages
627-630
Language
english
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
OBJECT: The purpose of this study was to demonstrate positron emission tomography (PET), histological, and immunohistochemical data supporting the notion of morphological redifferentiation in a malignant astrocytic tumor after gamma knife radiosurgery (GKS).
METHODS: The 11C- methionine-PET activity, Ki-67 labeling index (LI), and p53 protein expression were examined using immunohistochemical methods to assess tumor proliferative capacity. Tissue samples were obtained before and after radiosurgery in a patient with a malignant (Grade III) cerebellar astrocytoma. Positron emission tomography scans obtained 5.5 months following radiosurgery were suggestive of decreased tumor proliferative capacity and radionecrosis. Histological examination of tumor tissue removed 42 months before GKS was characteristic of a diffuse Grade III astrocytoma in every part of the resected tumor. Similar material removed 6 months after GKS was consistent with a Grade II astrocytoma in the great majority of the resected tumor.
CONCLUSIONS: Histopathological examination showed positive phenotypic modification (redifferentiation) consistent with a Grade 11 astrocytoma in the majority of tumor specimens after radiosurgery. After GKS both the Ki-67 LI and p53 reaction decreased considerably as did 11C methionine uptake. Because p53 is one of the essential genes involved in the radiation response, mutations induced by the ionizing effect of gamma rays might promote partial repair of this gene's tumor suppressor function.
Keywords
Adult, Astrocytoma/pathology, Astrocytoma/radionuclide imaging, Brain Neoplasms/pathology, Brain Neoplasms/radionuclide imaging, Cell Differentiation, Cell Division, Humans, Ki-67 Antigen/analysis, Radiosurgery, Tomography, Emission-Computed, Tumor Suppressor Protein p53/analysis
Pubmed
Web of science
Create date
20/01/2008 18:35
Last modification date
20/08/2019 13:36
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