The neuropeptide Y Y1 receptor regulates leptin-mediated control of energy homeostasis and reproductive functions.

Details

Serval ID
serval:BIB_0F9C3717746A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The neuropeptide Y Y1 receptor regulates leptin-mediated control of energy homeostasis and reproductive functions.
Journal
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Author(s)
Pralong F.P., Gonzales C., Voirol M.J., Palmiter R.D., Brunner H.R., Gaillard R.C., Seydoux J., Pedrazzini T.
ISSN
1530-6860[electronic]
Publication state
Published
Issued date
2002
Volume
16
Number
7
Pages
712-4
Language
english
Notes
Publication types: Journal Article - Publication Status: ppublish
Abstract
The orexigenic neurotransmitter neuropeptide Y (NPY) plays a central role in the hypothalamic control of food intake and energy balance. NPY also exerts an inhibition of the gonadotrope axis that could be important in the response to poor metabolic conditions. In contrast, leptin provides an anorexigenic signal to centrally control the body needs in energy. Moreover, leptin contributes to preserve adequate reproductive functions by stimulating the activity of the gonadotrope axis. It is of interest that hypothalamic NPY represents a primary target of leptin actions. To evaluate the importance of the NPY Y1 and Y5 receptors in the downstream pathways modulated by leptin and controlling energy metabolism as well as the activity of the gonadotrope axis, we studied the effects of leptin administration on food intake and reproductive functions in mice deficient for the expression of either the Y1 or the Y5 receptor. Furthermore, the role of the Y1 receptor in leptin resistance was determined in leptin-deficient ob/ob mice bearing a null mutation in the NPY Y1 locus. Results point to a crucial role for the NPY Y1 receptor in mediating the NPY pathways situated downstream of leptin actions and controlling food intake, the onset of puberty, and the maintenance of reproductive functions.
Keywords
Alleles, Animals, Anorexia, Body Weight, Energy Metabolism, Fasting, Female, Homeostasis, Hyperphagia, Kinetics, Leptin, Luteinizing Hormone, Male, Mice, Mice, Knockout, Models, Biological, Receptors, Leptin, Receptors, Neuropeptide Y, Sexual Maturation
Pubmed
Web of science
Create date
25/01/2008 8:45
Last modification date
20/08/2019 12:36
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