Reduction of small infrarenal abdominal aortic aneurysm expansion rate by statins.

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State: Public
Version: author
Serval ID
serval:BIB_0F961313B3B4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Reduction of small infrarenal abdominal aortic aneurysm expansion rate by statins.
Journal
VASA
Author(s)
Periard D., Guessous I., Mazzolai L., Haesler E., Monney P., Hayoz D.
ISSN
0301-1526 (Print)
ISSN-L
0301-1526
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
41
Number
1
Pages
35-42
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
BACKGROUND: To evaluate the effect of statins on the annual expansion rate (ER) of small infrarenal abdominal aortic aneurysms (AAA).
PATIENTS AND METHODS: All patients under regular surveillance for small AAA between January 2000 and September 2007, in the Department of Angiology, Lausanne University Hospital, were included. Inclusion criteria were baseline abdominal aortic diameter between 25 and 55 mm, at least two measurements of AAA diameter and a minimum follow up of 6 months. Patients with Marfan disease, infectious or inflammatory AAA, and patients with prior AAA repair were excluded. The influence of statin use and other factors on ER were examined by bivariate and multivariate analysis.
RESULTS: Among 589 patients who underwent an abdominal aorta evaluation, 94 patients (89 % men, mean age 69.1 years) were finally included in the analysis. Baseline AAA size was 39.9 ± 7.7 mm (mean±SE) and 48.7 ± 8.4 mm at end of follow-up. Patients had a regular aneurysm size assessment during 38.5 ± 27.7 months. Mean ER was 3.59 mm/y (± 2.81). The 50 patients who were treated with statin during the study period had a lower ER compared to the 44 controls (2.91 vs 4.37 mm/year, p = 0.01).
CONCLUSIONS: This study confirms the considerable individual variations in the AAA expansion rate, and emphasizes the need for regular aortic diameter assessments. In this study, patients treated with statin demonstrate a significant decrease in the ER compared to controls. This finding need to be evaluated in prospective interventional studies powered to demonstrate the potential benefit of statin treatment.
Keywords
Aged, Aorta, Abdominal/drug effects, Aorta, Abdominal/radiography, Aortic Aneurysm, Abdominal/diagnosis, Aortic Aneurysm, Abdominal/drug therapy, Aortography/methods, Chi-Square Distribution, Disease Progression, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Linear Models, Male, Middle Aged, Multivariate Analysis, Retrospective Studies, Risk Assessment, Risk Factors, Switzerland, Time Factors, Tomography, X-Ray Computed, Treatment Outcome
Pubmed
Web of science
Create date
20/01/2012 8:51
Last modification date
29/12/2019 7:08
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