De novo hemolytic uremic syndrome postrenal transplant after cytomegalovirus infection

Details

Serval ID
serval:BIB_0F6F5F183FB1
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
De novo hemolytic uremic syndrome postrenal transplant after cytomegalovirus infection
Journal
American Journal of Kidney Diseases
Author(s)
Waiser  J., Budde  K., Rudolph  B., Ortner  M. A., Neumayer  H. H.
ISSN
1523-6838 (Electronic)
Publication state
Published
Issued date
09/1999
Volume
34
Number
3
Pages
556-9
Notes
Case Reports
Journal Article --- Old month value: Sep
Abstract
After renal transplantation, hemolytic uremic syndrome (HUS) may occur as recurrent disease or de novo. Here, we describe the de novo occurrence of HUS immediately after the onset of primary cytomegalovirus (CMV) disease in two renal allograft recipients. Patient no. 1 had primary CMV disease with biopsy-proven CMV esophagitis 2 months after transplantation. Patient no. 2 experienced primary CMV disease with fever and leukopenia 8 years after transplantation. Both patients were treated with intravenous ganciclovir. Both patients developed HUS with biopsy-proven thrombotic microangiopathy in the renal allograft only a few days (3 to 5 days) after the onset of CMV disease. The short interval between the onset of CMV disease and HUS, as well as the parallel course of CMV viremia and HUS in both patients, indicate there may be a pathophysiological link between both diseases. However, because antiviral therapy with ganciclovir was started before the onset of HUS in both patients, we cannot definitely rule out that HUS was triggered by ganciclovir.
Keywords
Adult Antiviral Agents/administration & dosage/adverse effects Cytomegalovirus Infections/drug therapy/*pathology Ganciclovir/administration & dosage/adverse effects Hemolytic-Uremic Syndrome/*pathology Humans Kidney Glomerulus/pathology Kidney Transplantation/*pathology Male Postoperative Complications/drug therapy/*pathology Recurrence Risk Factors
Pubmed
Web of science
Create date
25/01/2008 17:08
Last modification date
20/08/2019 13:36
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