Primary extramedullary plasmacytoma: similarities with and differences from multiple myeloma revealed by interphase cytogenetics.

Details

Serval ID
serval:BIB_0F618829A382
Type
Article: article from journal or magazin.
Collection
Publications
Title
Primary extramedullary plasmacytoma: similarities with and differences from multiple myeloma revealed by interphase cytogenetics.
Journal
Haematologica
Author(s)
Bink K., Haralambieva E., Kremer M., Ott G., Beham-Schmid C., de Leval L., Peh S.C., Laeng H.R., Jütting U., Hutzler P., Quintanilla-Martinez L., Fend F.
ISSN
0390-6078
ISSN-L
1592-8721[electronic],
Publication state
Published
Issued date
2008
Volume
93
Number
4
Pages
623-626
Language
english
Abstract
Primary extramedullary plasmacytoma is an indolent neoplasm that infrequently converts to multiple myeloma. Since cytogenetic data on extramedullary plasmacytoma are lacking, we studied 38 cases of this type of neoplasm by fluorescence in situ hybridization. Fourteen cases (37%) contained IGH breaks, including six with a t(4;14) translocation. No translocations t(11;14), t(14;16), t(8;14), nor breaks involving MALT1, BCL6 or FOXP1 were found. Loss of 13q (40%), as well as chromosomal gains (82%) were common. There was no correlation between chromosomal alterations and clinical features or local relapse. Cytogenetically, extramedullary plasmacytoma and multiple myeloma are closely related. However, the distribution of IGH translocation partners, with the notable absence of t(11;14), is different. Key words: extramedullary plasmacytoma, multiple myeloma, cytogenetics, IGH translocation, fluorescence in situ hybridization.
Keywords
Adult, Aged, Aged, 80 and over, Aneuploidy, Chromosome Aberrations, Digestive System Neoplasms/genetics, Digestive System Neoplasms/pathology, Female, Genes, Immunoglobulin, Humans, Immunoglobulin Heavy Chains/genetics, In Situ Hybridization, Fluorescence, Interphase, Male, Middle Aged, Multiple Myeloma/genetics, Multiple Myeloma/pathology, Oncogene Proteins, Fusion/genetics, Plasmacytoma/genetics, Plasmacytoma/pathology, Respiratory Tract Neoplasms/genetics, Respiratory Tract Neoplasms/pathology, Sequence Deletion, Soft Tissue Neoplasms/genetics, Soft Tissue Neoplasms/pathology, Translocation, Genetic
Pubmed
Create date
27/10/2010 8:46
Last modification date
20/08/2019 12:36
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