Genotype 3 is associated with rapid histological progression in chronic HCV infection


Serval ID
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Genotype 3 is associated with rapid histological progression in chronic HCV infection
Title of the conference
Joint annual congress of the Swiss Society for Allergology and Immunology and Swiss Society for Infectious Diseases, Geneva, March 19/20, 2009
Bochud Pierre-Yves, Overbeck Kathrin, Bochud Murielle, Rickenbach Martin, Dufour Jean-François, Muellhaupt B., Borovicka Jan, Heim Markus, Moradpour Darius, Cerny Andreas, Malinverni Raffaele, Francioli Patrick, Negro Francesco
Working group(s)
Swiss Hepatitis C Cohort Study Group
Publication state
Issued date
Swiss Medical Weekly
While several risk factors for the histological progression of chronic hepatitis C have been identified, the contribution of HCV genotypes to liver fibrosis evolution remains controversial. The aim of the present study was to assess independent predictors for fibrosis progression.
Methods: We identified 1540 patients from the Swiss Hepatitis C Cohort database with at least one liver biopsy prior to antiviral treatment. Factors associated with fibrosis stage, steatosis and histological activity were assessed in univariate and multivariate regression models. Fibrosis progression rate per year was calculated in a subgroup of 1263 patients, in whom risk factors were assessed by cumulative incidence curves, logistic and linear regression models.
Results: Independent risk factors for rapid fibrosis progression included male sex (OR = 1.66, 95% CI 1.25-2.21, P <0.001), age at infection (OR = 1.08, 95% CI 1.06-1.10, P <0.001), histological activity (OR = 2.14, 95% CI 1.61-2.85, P <0.001) and genotype 3 (OR = 1.97, 95% CI 1.43-2.72, P <0.001). Genotype 2 was associated with slow progression (OR = 0.51, 95% CI 0.30-0.89, P = 0.02), but this observation may be due to the decreased prevalence of genotype 2 over the last decades, leading to an overrepresentation of subjects with genotype 2 with a slow progression rate. Conclusion: This study shows a significant association of genotype 3 with accelerated fibrosis. While assessing risk factors for fibrosis progression, the changing epidemiology of HCV genotypes over time needs to be taken into account.
Create date
12/02/2010 10:03
Last modification date
20/08/2019 12:35
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