Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system?

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Serval ID
serval:BIB_0ECBA4BF3B77
Type
Article: article from journal or magazin.
Publication sub-type
Editorial
Collection
Publications
Institution
Title
Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system?
Journal
Nature Reviews. Immunology
Author(s)
Reizis B., Colonna M., Trinchieri G., Barrat F., Gilliet M.
ISSN
1474-1741 (Electronic)
ISSN-L
1474-1733
Publication state
Published
Issued date
2011
Volume
11
Number
8
Pages
558-565
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural. Perspectives.
Publication Status: epublish
Abstract
Plasmacytoid dendritic cells (pDCs) were first described as interferon-producing cells and, for many years, their overlapping characteristics with both lymphocytes and classical dendritic cells (cDCs) created confusion over their exact ontogeny. In this Viewpoint article, Nature Reviews Immunology asks five leaders in the field to discuss their thoughts on the development and functions of pDCs--do these cells serve mainly as a major source of type I interferons or do they also make other important contributions to immune responses?
Keywords
Animals, Antigen Presentation/immunology, Autoimmune Diseases/immunology, Autoimmune Diseases/therapy, Cell Differentiation/immunology, Dendritic Cells/cytology, Dendritic Cells/immunology, Graft Rejection/immunology, Graft Rejection/prevention & control, Humans, Immune Tolerance/immunology, Inflammation/immunology, Interferon Type I/metabolism, Leukemia/immunology, Leukemia/therapy, Mice, Neoplasms/immunology, Neoplasms/therapy, T-Lymphocytes/cytology, T-Lymphocytes/immunology, Toll-Like Receptor 7/metabolism, Toll-Like Receptor 9/metabolism, Virus Diseases/immunology, Virus Diseases/therapy
Pubmed
Web of science
Open Access
Yes
Create date
05/10/2011 10:43
Last modification date
20/08/2019 12:35
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