Intellectual outcome in children and adolescents with acute lymphoblastic leukaemia treated with chemotherapy alone: age- and sex-related differences.

Details

Serval ID
serval:BIB_0EC229E53FD4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Intellectual outcome in children and adolescents with acute lymphoblastic leukaemia treated with chemotherapy alone: age- and sex-related differences.
Journal
European Journal of Cancer
Author(s)
von der Weid N., Mosimann I., Hirt A., Wacker P., Nenadov Beck M., Imbach P., Caflisch U., Niggli F., Feldges A., Wagner H.P.
ISSN
0959-8049
Publication state
Published
Issued date
2003
Peer-reviewed
Oui
Volume
39
Number
3
Pages
359-365
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
One of the most relevant concerns in long-term survivors of paediatric acute lymphoblastic leukaemia (ALL) is the development of neuropsychological sequelae. The majority of the published studies report on patients treated with chemotherapy and prophylactic central nervous system (CNS) irradiation, little is known about the outcome of patients treated with chemotherapy-only regimens. Using the standardised clinical and neuropsychological instruments of the SPOG Late Effects Study, the intellectual performance of 132 paediatric ALL patients treated with chemotherapy only was compared to that of 100 control patients surviving from diverse non-CNS solid tumours. As a group, ALL and solid tumour survivors showed normal and comparable intellectual performances (mean global IQ 104.6 in both groups). The percentage of patients in the borderline range (global IQ between 70 and 85) was comparable and not higher as expected (10% cases and 13% controls, expected 16%). Only 2 (2%) of the former ALL and 1 (1%) of the solid tumour patients were in the range of mental retardation (global IQ<70). Former known risk factors described in children treated with prophylactic CNS irradiation, like a younger age at diagnosis of ALL and female gender, remained valid in chemotherapy-only treated patients. The abandonment of prophylactic CNS irradiation and its replacement by a more intensive systemic and intrathecal chemotherapy led to a reduction, but not the disappearance of late neuropsychological sequelae.
Keywords
Adolescent, Analysis of Variance, Antineoplastic Combined Chemotherapy Protocols/adverse effects, Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, Infant, Intelligence/drug effects, Intelligence Tests, Male, Neuropsychological Tests, Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy, Precursor Cell Lymphoblastic Leukemia-Lymphoma/psychology, Sex Factors, Survivors/psychology
Pubmed
Web of science
Create date
20/03/2008 9:34
Last modification date
20/08/2019 12:35
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