Cyclo His-Pro Attenuates Muscle Degeneration in Murine Myopathy Models.

Details

Serval ID
serval:BIB_0EBEAE2F135F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cyclo His-Pro Attenuates Muscle Degeneration in Murine Myopathy Models.
Journal
Advanced science
Author(s)
De Masi A., Zanou N., Strotjohann K., Lee D., Lima T.I., Li X., Jeon J., Place N., Jung H.Y., Auwerx J.
ISSN
2198-3844 (Electronic)
ISSN-L
2198-3844
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Among the inherited myopathies, a group of muscular disorders characterized by structural and metabolic impairments in skeletal muscle, Duchenne muscular dystrophy (DMD) stands out for its devastating progression. DMD pathogenesis is driven by the progressive degeneration of muscle fibers, resulting in inflammation and fibrosis that ultimately affect the overall muscle biomechanics. At the opposite end of the spectrum of muscle diseases, age-related sarcopenia is a common condition that affects an increasing proportion of the elderly. Although characterized by different pathological mechanisms, DMD and sarcopenia share the development of progressive muscle weakness and tissue inflammation. Here, the therapeutic effects of Cyclo Histidine-Proline (CHP) against DMD and sarcopenia are evaluated. In the mdx mouse model of DMD, it is shown that CHP restored muscle contractility and force production, accompanied by the reduction of fibrosis and inflammation in skeletal muscle. CHP furthermore prevented the development of cardiomyopathy and fibrosis in the diaphragm, the two leading causes of death for DMD patients. CHP also attenuated muscle atrophy and functional deterioration in a mouse model of age-related sarcopenia. These findings from two different models of muscle dysfunction hence warrant further investigation into the effects of CHP on muscle pathologies in animal models and eventually in patients.
Keywords
Duchenne muscular dystrophy, cardiomyopathy, mitochondrial dysfunction, muscle fibrosis, sarcopenia
Pubmed
Web of science
Create date
16/05/2024 14:58
Last modification date
25/05/2024 7:12
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