Pulsatile secretion of gonadotropins and prolactin during the follicular and luteal phases of the menstrual cycle: analysis of instantaneous secretion rate and secretory concomitance

Details

Serval ID
serval:BIB_0E6C752CC865
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Pulsatile secretion of gonadotropins and prolactin during the follicular and luteal phases of the menstrual cycle: analysis of instantaneous secretion rate and secretory concomitance
Journal
Fertility and Sterility
Author(s)
Inaudi  P., Reymond  M. J., Rey  F., Genazzani  A. D., Lemarchand-Beraud  T.
ISSN
0015-0282
Publication state
Published
Issued date
07/1992
Peer-reviewed
Oui
Volume
58
Number
1
Pages
51-9
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Abstract
OBJECTIVE: To characterize the pulsatile secretions of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and prolactin (PRL) during the menstrual cycle and to statistically evaluate their secretory concomitance. DESIGN: Pulsatility study performed during the midfollicular and midluteal phases of a same menstrual cycle, blood samples being collected every 10 minutes for 6 hours. SETTING: Participants investigated in the Division of Endocrinology, University Hospital. PARTICIPANTS: Nine healthy women (22 to 38 years) with regular menstrual cycles. MAIN OUTCOME MEASURES: Plasma LH, FSH, and PRL values were analyzed as raw and deconvoluted data, and the specific (nonrandom) secretory concomitance was evaluated statistically. RESULTS: The pulsatile secretion of LH was confirmed, and that of FSH and PRL was clearly established during both phases of the cycle by characterization of peak frequency, period, and amplitude. A specific secretory concomitance was assessed between LH and FSH in the follicular but not the luteal phase, and a tight concomitance between LH and PRL was demonstrated during both phases. CONCLUSIONS: These results are supportive of significant pulsatile secretions of the three hormones during the menstrual cycle, and they are demonstrative of a definite copulsatility of these hormones, suggestive of common regulatory factors in the complex temporal patterns of gonadotropin and PRL secretions along the cycle.
Keywords
Adult Female Follicle Stimulating Hormone/blood Follicular Phase/*physiology Gonadotropins/*blood Humans Luteal Phase/*physiology Luteinizing Hormone/blood Menstrual Cycle/*physiology Prolactin/*blood Time Factors
Pubmed
Web of science
Create date
11/02/2008 14:12
Last modification date
20/08/2019 12:35
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