Novel acquisitions in the diagnosis of medullary thyroid carcinoma.

Details

Serval ID
serval:BIB_0E37383D7FB6
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Novel acquisitions in the diagnosis of medullary thyroid carcinoma.
Journal
Minerva endocrinologica
Author(s)
Trimboli P., Crescenzi A., Saggiorato E., Treglia G., Giovanella L.
ISSN
1827-1634 (Electronic)
ISSN-L
0391-1977
Publication state
Published
Issued date
09/2017
Peer-reviewed
Oui
Volume
42
Number
3
Pages
238-247
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The correct identification of medullary thyroid carcinoma (MTC) has been a challenge since its first description. In the last few years, some advances in this context have been achieved. Here we aimed to review and discuss published data on the more recent acquisition in the diagnosis of MTC.
A literature search of the medical databases was conducted by searching papers reporting tool for diagnosis of MTC published in the last years. The search was updated until July 2016.
The literature search revealed several relevant articles which focused on different topics of the diagnosis of MTC. The results are reported by four paragraphs, such as 1) fine-needle aspiration; 2) molecular analysis; 3) serum markers; 4) imaging.
The measurement of calcitonin in FNA washout fluids is essential due to poor accuracy of conventional cytology to detect MTC. Genetic analysis can help to identify those advanced MTC with poorer prognosis who do not respond to chemotherapy. Procalcitonin may in the next future replace calcitonin as serum diagnostic marker of MTC. Recent evidence based data seem to suggest the emerging role of functional imaging in recurrent MTC in patients with calcitonin serum levels >150 pg/mL.

Pubmed
Create date
20/08/2017 16:32
Last modification date
20/08/2019 12:35
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