On the interplay effect for moving targets treated with the CyberKnife static tracking system.

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State: Public
Version: author
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_0E0223D7988A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
On the interplay effect for moving targets treated with the CyberKnife static tracking system.
Journal
Physica medica
Author(s)
Zeverino M., Jia Y., Charosky L., Bourhis J., Bochud F.O., Moeckli R.
ISSN
1724-191X (Electronic)
ISSN-L
1120-1797
Publication state
Published
Issued date
13/09/2021
Peer-reviewed
Oui
Volume
90
Pages
30-39
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
To assess the interplay effect amplitude between different planned MU distributions and respiratory patterns in the CyberKnife system when treating moving targets with static tracking technique.
Small- and Large-Respiratory Motions (SRM and LRM) differing in amplitude and frequency were simulated in a semi-anthropomorphic dynamic thorax phantom. The interplay effect was evaluated for both respiration motions in terms of GTV coverage and conformity for three plans designed with an increasing range of MU per beam (small, medium and large). Each plan was delivered three times changing the initial beam-on phase to assess the inter-fraction variation. Dose distributions were measured using radiochromic films placed in the GTV axial and sagittal planes.
Generally, SRM plans gave higher GTV coverage and were less dependent on beam-on phases than LRM plans. For SRM (LRM) plans, the GTV coverage ranged from 95.2% to 99.7% (85.9% to 99.8%). Maximum GTV coverage was found for large MU plans in SRM and for small MU plans in LRM. Minimum GTV coverage was found for medium MU plans for both SRM and LRM. For SRM plans, dose conformity decreased with increasing MU range while the variation was reduced for LRM plans. Large MU plans reduced the inter-fraction variation for SRM and LRM.
We confirmed the interplay effect between target motion and beam irradiation time for CyberKnife static tracking. Plans with large MU per beam improved the GTV coverage for small motion amplitude and the inter-fraction dose variation for large motion amplitude.
Keywords
CyberKnife static tracking technique, Gafchromic EBT3, Interplay effect, Lung SBRT
Pubmed
Web of science
Open Access
Yes
Create date
27/09/2021 11:31
Last modification date
03/11/2021 6:39
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