Impact of micrometastasis or isolated tumor cells on recurrence and survival in patients with early cervical cancer: SENTICOL Trial.

Details

Serval ID
serval:BIB_0DE2936F9D62
Type
Article: article from journal or magazin.
Collection
Publications
Title
Impact of micrometastasis or isolated tumor cells on recurrence and survival in patients with early cervical cancer: SENTICOL Trial.
Journal
International journal of gynecological cancer
Author(s)
Guani B., Dorez M., Magaud L., Buenerd A., Lecuru F., Mathevet P.
ISSN
1525-1438 (Electronic)
ISSN-L
1048-891X
Publication state
Published
Issued date
03/2019
Peer-reviewed
Oui
Volume
29
Number
3
Pages
447-452
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The aim of this study was to evaluate the impact of micrometastasis and isolated tumor cells on disease recurrence in patients with early-stage cervical cancer.
We included patients with International Federation of Gynecology and Obstetrics (FIGO) stage IA1 with lymphvascular space invasion, stage IA2, and IB1 who participated in the SENTICOL1 trial. A centralized histologic analysis with re-reading and ultrastaging was performed 3 months after surgery and treatment was not impacted by findings from our study. Patients were followed for 3 years and outcomes were compared according to prognostic factors.
A total of 139 patients were included and 13 recurrences were found. There were two recurrences in patients with positive sentinel lymph node (SLN) (one macrometastases and one micrometastases) and 11 recurrences in patients with negative lymph nodes (sentinel or non-sentinel). Among patients with positive SLN for micrometastases there was only one recurrence. No patient with isolated tumor cells on their lymph nodes experienced a recurrence. There was a significant decrease in disease-free survival in patients aged >50 years (p = 0.01).
Evidence of micrometastasis or isolated tumor cells in the SLN of untreated patients with early cervical cancer in the SENTICOL1 trial did not impact progression-free survival.
Keywords
Aged, Female, France/epidemiology, Humans, Longitudinal Studies, Middle Aged, Neoplasm Micrometastasis, Neoplasm Recurrence, Local/mortality, Neoplasm Recurrence, Local/pathology, Prospective Studies, Sentinel Lymph Node/pathology, Uterine Cervical Neoplasms/diagnostic imaging, Uterine Cervical Neoplasms/mortality, Uterine Cervical Neoplasms/pathology, Uterine Cervical Neoplasms/therapy, cervical cancer, micrometastasis, sentinel lymph node
Pubmed
Web of science
Open Access
Yes
Create date
07/04/2019 15:09
Last modification date
24/01/2020 7:19
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