The effect of ageing on function and quality of life in ileal pouch patients: a single cohort experience of 409 patients with chronic ulcerative colitis.

Details

Serval ID
serval:BIB_0DE1BA243D99
Type
Article: article from journal or magazin.
Collection
Publications
Title
The effect of ageing on function and quality of life in ileal pouch patients: a single cohort experience of 409 patients with chronic ulcerative colitis.
Journal
Annals of Surgery
Author(s)
Hahnloser D., Pemberton J.H., Wolff B.G., Larson D.R., Crownhart B.S., Dozois R.R.
ISSN
0003-4932 (Print)
ISSN-L
0003-4932
Publication state
Published
Issued date
2004
Volume
240
Number
4
Pages
615-621; discussion 621-623
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
OBJECTIVE: To evaluate in what manner ageing affects functional outcome and quality of life (QoL) in patients with chronic ulcerative colitis (CUC) after ileal pouch-anal anastomosis (IPAA).
SUMMARY BACKGROUND DATA: Short-term function and QoL after IPAA is good. However, patients are usually young, and little is known about the influence of time and ageing on long-term outcomes after IPAA.
METHODS: Using a standardized questionnaire, functional outcome, QoL, and complications were assessed prospectively in a cohort of 409 patients followed annually for 15 years after IPAA.
RESULTS: Follow-up was complete in the single cohort of 409 patients and functional and QoL outcomes summarized at 5, 10, and 15 years. Daytime stool frequency changed little (mean 6), while nighttime frequency increased from 1 stool to 2 stools. Incontinence for gas and stool increased from 1% to 10% during the day and from 2% to 24% at night over 15 years. The cumulative probability of pouchitis increased from 28% at 5 years to 38% at 10 years and to 47% at 15 years. Bowel obstruction and stricture were other principal long-term complications. At 15 years, 91% of patients had kept the same job. Work was not affected by the surgery in 83%, while social activities, sports, traveling, and sexual life all improved after surgery and did not deteriorate over time.
CONCLUSIONS: These long-term results in a single cohort of 409 IPAA patients are unique and are likely a more accurate reflection of long-term outcome than has been previously reported. These data support the conclusion that IPAA is a durable operation for patients requiring proctocolectomy for CUC; functional and QoL outcomes are good, predictable, and stable for 15 years after operation.
Keywords
Activities of Daily Living, Adolescent, Adult, Aging/physiology, Cohort Studies, Colitis, Ulcerative/surgery, Colonic Diseases/etiology, Colonic Pouches/physiology, Constriction, Pathologic/etiology, Defecation/physiology, Employment, Fecal Incontinence/etiology, Female, Follow-Up Studies, Humans, Intestinal Obstruction/etiology, Leisure Activities, Male, Middle Aged, Patient Satisfaction, Pouchitis/etiology, Prospective Studies, Quality of Life, Treatment Outcome
Pubmed
Web of science
Create date
07/10/2014 13:46
Last modification date
20/08/2019 12:34
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