Beta-blockade with nebivolol enhances the acetylcholine-induced cutaneous vasodilation.

Details

Serval ID
serval:BIB_0DAC882F3444
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Beta-blockade with nebivolol enhances the acetylcholine-induced cutaneous vasodilation.
Journal
Clinical Pharmacology and Therapeutics
Author(s)
Kubli S., Feihl F., Waeber B.
ISSN
0009-9236
Publication state
Published
Issued date
2001
Peer-reviewed
Oui
Volume
69
Number
4
Pages
238-244
Language
english
Notes
Publication types: Clinical Trial ; Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't -
Abstract
Nebivolol is a selective beta(1)-adrenoceptor blocker that has a vasorelaxant activity thought to be the result of a facilitation of the release of nitric oxide from the endothelium. This study was undertaken in 12 healthy male volunteers to assess whether this compound increases the vasodilatory response to acetylcholine when administered orally at a dose commonly recommended for the treatment of cardiovascular diseases. The subjects were randomly allocated to an 8-day treatment with nebivolol (5 mg once a day) and atenolol (50 mg once a day) according to a cross-over design. The two treatments were separated by a 1-week washout period. On the first and the last day of each treatment phase, both before drug administration and 3 hours after drug administration, the forearm skin blood flow response to acetylcholine applied by iontophoresis was determined with the use of a laser Doppler scanner imaging system. The reactivity to acetylcholine was significantly increased 3 hours after the administration of nebivolol on both the first and the last day of treatment, whereas atenolol had no effect on this parameter. These data therefore indicate that nebivolol, but not atenolol, enhances the vasorelaxant activity of acetylcholine in the skin vascular bed; this is compatible with a facilitation by this beta-blocker of the endothelium-dependent vasodilation.
Keywords
Acetylcholine, Adrenergic beta-Antagonists, Adult, Antihypertensive Agents, Atenolol, Benzopyrans, Blood Pressure, Cross-Over Studies, Drug Synergism, Ethanolamines, Heart Rate, Humans, Iontophoresis, Laser-Doppler Flowmetry, Male, Random Allocation, Regional Blood Flow, Skin, Temperature, Vasodilation, Vasodilator Agents
Pubmed
Web of science
Create date
25/01/2008 9:38
Last modification date
20/08/2019 12:34
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