Definition, diagnosis and treatment of oligometastatic oesophagogastric cancer: A Delphi consensus study in Europe.

Kroese, T.E.; van Laarhoven, HWM; Schoppman, S.F.; Deseyne, PRAJ; van Cutsem, E.; Haustermans, K.; Nafteux, P.; Thomas, M.; Obermannova, R.; Mortensen, H.R.; Nordsmark, M.; Pfeiffer, P.; Elme, A.; Adenis, A.; Piessen, G.; Bruns, C.J.; Lordick, F.; Gockel, I.; Moehler, M.; Gani, C.; Liakakos, T.; Reynolds, J.; Morganti, A.G.; Rosati, R.; Castoro, C.; Cellini, F.; D'Ugo, D.; Roviello, F.; Bencivenga, M.; de Manzoni, G.; van Berge Henegouwen, M.I.; Hulshof, MCCM; van Dieren, J.; Vollebergh, M.; van Sandick, J.W.; Jeene, P.; Muijs, C.T.; Slingerland, M.; Voncken, FEM; Hartgrink, H.; Creemers, G.J.; van der Sangen, MJC; Nieuwenhuijzen, G.; Berbee, M.; Verheij, M.; Wijnhoven, B.; Beerepoot, L.V.; Mohammad, N.H.; Mook, S.; Ruurda, J.P.; Kolodziejczyk, P.; Polkowski, W.P.; Wyrwicz, L.; Alsina, M.; Pera, M.; Kanonnikoff, T.F.; Cervantes, A.; Nilsson, M.; Monig, S.; Wagner, A.D.; Guckenberger, M.; Griffiths, E.A.; Smyth, E.; Hanna, G.B.; Markar, S.; Chaudry, M.A.; Hawkins, M.A.; Cheong, E.; van Hillegersberg, R.; van Rossum, PSN

doi:10.1016/j.ejca.2023.02.015

Definition, diagnosis and treatment of oligometastatic oesophagogastric cancer: A Delphi consensus study in Europe.

Details

Download: 36947929.pdf (1584.51 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0

Serval ID

serval:BIB_0D7216745F58

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Definition, diagnosis and treatment of oligometastatic oesophagogastric cancer: A Delphi consensus study in Europe.

Journal

European journal of cancer

Author(s)

Kroese T.E., van Laarhoven HWM, Schoppman S.F., Deseyne PRAJ, van Cutsem E., Haustermans K., Nafteux P., Thomas M., Obermannova R., Mortensen H.R., Nordsmark M., Pfeiffer P., Elme A., Adenis A., Piessen G., Bruns C.J., Lordick F., Gockel I., Moehler M., Gani C., Liakakos T., Reynolds J., Morganti A.G., Rosati R., Castoro C., Cellini F., D'Ugo D., Roviello F., Bencivenga M., de Manzoni G., van Berge Henegouwen M.I., Hulshof MCCM, van Dieren J., Vollebergh M., van Sandick J.W., Jeene P., Muijs C.T., Slingerland M., Voncken FEM, Hartgrink H., Creemers G.J., van der Sangen MJC, Nieuwenhuijzen G., Berbee M., Verheij M., Wijnhoven B., Beerepoot L.V., Mohammad N.H., Mook S., Ruurda J.P., Kolodziejczyk P., Polkowski W.P., Wyrwicz L., Alsina M., Pera M., Kanonnikoff T.F., Cervantes A., Nilsson M., Monig S., Wagner A.D., Guckenberger M., Griffiths E.A., Smyth E., Hanna G.B., Markar S., Chaudry M.A., Hawkins M.A., Cheong E., van Hillegersberg R., van Rossum PSN

Working group(s)

OMEC collaborators

Contributor(s)

Rozema T., Heisterkamp J., Schaefer M., Ozsahin E.M., de Haan J., Willem van den Berg J., Duprez F., Callebout E., van Daele E., Hacker U., Hoffmeister A., Kuhnt T., Denecke T., Kluge R., Prager G., Ilhan-Mutlu A., Cuicchi D., Ardizzoni A., Rosman C., Gootjes E.C., Rütten H., Puccetti F., Cascinu S., Slim N., Barrios M.E., Fernandez M.C., Martí-Oriol R., Alvaro M.H., Vera A., Jordá E., Mozos F.L., Reig A., Visa L., Ciseł B., Czechowska J., Kwietniewska M., Pikuła A., Skórzewska M., Kozłowska A., Rawicz-Pruszyński K.

ISSN

1879-0852 (Electronic)

ISSN-L

0959-8049

Publication state

Published

Issued date

05/2023

Peer-reviewed

Oui

Volume

185

Pages

28-39

Language

english

Notes

Publication types: Systematic Review ; Journal Article
Publication Status: ppublish

Abstract

Local treatment improves the outcomes for oligometastatic disease (OMD, i.e. an intermediate state between locoregional and widespread disseminated disease). However, consensus about the definition, diagnosis and treatment of oligometastatic oesophagogastric cancer is lacking. The aim of this study was to develop a multidisciplinary European consensus statement on the definition, diagnosis and treatment of oligometastatic oesophagogastric cancer.
In total, 65 specialists in the multidisciplinary treatment for oesophagogastric cancer from 49 expert centres across 16 European countries were requested to participate in this Delphi study. The consensus finding process consisted of a starting meeting, 2 online Delphi questionnaire rounds and an online consensus meeting. Input for Delphi questionnaires consisted of (1) a systematic review on definitions of oligometastatic oesophagogastric cancer and (2) a discussion of real-life clinical cases by multidisciplinary teams. Experts were asked to score each statement on a 5-point Likert scale. The agreement was scored to be either absent/poor (<50%), fair (50%-75%) or consensus (≥75%).
A total of 48 experts participated in the starting meeting, both Delphi rounds, and the consensus meeting (overall response rate: 71%). OMD was considered in patients with metastatic oesophagogastric cancer limited to 1 organ with ≤3 metastases or 1 extra-regional lymph node station (consensus). In addition, OMD was considered in patients without progression at restaging after systemic therapy (consensus). For patients with synchronous or metachronous OMD with a disease-free interval ≤2 years, systemic therapy followed by restaging to consider local treatment was considered as treatment (consensus). For metachronous OMD with a disease-free interval >2 years, either upfront local treatment or systemic treatment followed by restaging was considered as treatment (fair agreement).
The OMEC project has resulted in a multidisciplinary European consensus statement for the definition, diagnosis and treatment of oligometastatic oesophagogastric adenocarcinoma and squamous cell cancer. This can be used to standardise inclusion criteria for future clinical trials.

Keywords

Humans, Delphi Technique, Neoplasms, Europe, Gastric cancer, Metastasectomy, Metastasis, Oesophageal cancer, Oligometastasis, Stereotactic body radiotherapy

URN

urn:nbn:ch:serval-BIB_0D7216745F583

OAI-PMH

oai:serval.unil.ch:BIB_0D7216745F58

DOI

10.1016/j.ejca.2023.02.015

Pubmed

36947929

Web of science

000982949200001

Open Access

Yes