Diagnostic and Prognostic Impact of pc-ASPECTS Applied to Perfusion CT in the Basilar Artery International Cooperation Study.

Details

Serval ID
serval:BIB_0D45CD8D1375
Type
Article: article from journal or magazin.
Collection
Publications
Title
Diagnostic and Prognostic Impact of pc-ASPECTS Applied to Perfusion CT in the Basilar Artery International Cooperation Study.
Journal
Journal of Neuroimaging
Author(s)
Pallesen L.P., Gerber J., Dzialowski I., van der Hoeven E.J., Michel P., Pfefferkorn T., Ozdoba C., Kappelle L.J., Wiedemann B., Khomenko A., Algra A., Hill M.D., von Kummer R., Demchuk A.M., Schonewille W.J., Puetz V.
Working group(s)
BASICS Study Group
ISSN
1552-6569 (Electronic)
ISSN-L
1051-2284
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
25
Number
3
Pages
384-389
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
BACKGROUND AND PURPOSE: The posterior circulation Acute Stroke Prognosis Early CT Score (pc-APECTS) applied to CT angiography source images (CTA-SI) predicts the functional outcome of patients in the Basilar Artery International Cooperation Study (BASICS). We assessed the diagnostic and prognostic impact of pc-ASPECTS applied to perfusion CT (CTP) in the BASICS registry population.
METHODS: We applied pc-ASPECTS to CTA-SI and cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) parameter maps of BASICS patients with CTA and CTP studies performed. Hypoattenuation on CTA-SI, relative reduction in CBV or CBF, or relative increase in MTT were rated as abnormal.
RESULTS: CTA and CTP were available in 27/592 BASICS patients (4.6%). The proportion of patients with any perfusion abnormality was highest for MTT (93%; 95% confidence interval [CI], 76%-99%), compared with 78% (58%-91%) for CTA-SI and CBF, and 46% (27%-67%) for CBV (P < .001). All 3 patients with a CBV pc-ASPECTS < 8 compared to 6/23 patients with a CBV pc-ASPECTS ≥ 8 had died at 1 month (RR 3.8; 95% CI, 1.9-7.6).
CONCLUSION: CTP was performed in a minority of the BASICS registry population. Perfusion disturbances in the posterior circulation were most pronounced on MTT parameter maps. CBV pc-ASPECTS < 8 may indicate patients with high case fatality.
Pubmed
Web of science
Create date
31/05/2015 9:35
Last modification date
03/03/2018 13:39
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