Scarless excision of an insertion sequence restores capsule production and virulence in Acinetobacter baumannii.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_0D1DC6EBFBDC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
UNIL/CHUV
Title
Scarless excision of an insertion sequence restores capsule production and virulence in Acinetobacter baumannii.
Journal
The ISME journal
Author(s)
Whiteway C., Valcek A., Philippe C., Strazisar M., De Pooter T., Mateus I., Breine A., Van der Henst C.
ISSN
1751-7370 (Electronic)
ISSN-L
1751-7362
Publication state
Published
Issued date
05/2022
Peer-reviewed
Oui
Volume
16
Number
5
Pages
1473-1477
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
We identify a new mechanism mediating capsule production and virulence in the WHO and CDC priority ESKAPE pathogen Acinetobacter baumannii. Non-capsulated and avirulent bacteria can revert into a capsulated and virulent state upon scarless excision of an ISAba13 insertion sequence under stress conditions. Reversion events fully restore capsule production and in vivo virulence. This increases our knowledge about A. baumannii genome dynamics, and the regulation of capsule production, virulence and resistance.
Keywords
Acinetobacter Infections/genetics, Acinetobacter Infections/microbiology, Acinetobacter baumannii/genetics, DNA Transposable Elements, Humans, Virulence/genetics, Virulence Factors/genetics
URN
urn:nbn:ch:serval-BIB_0D1DC6EBFBDC2
OAI-PMH
oai:serval.unil.ch:BIB_0D1DC6EBFBDC
DOI
10.1038/s41396-021-01179-3
Pubmed
34949784
Web of science
000734147600001
Open Access
Yes
Create date
04/01/2022 8:42
Last modification date
23/01/2024 7:20
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