Initial antimicrobial management of sepsis.

Details

Serval ID
serval:BIB_0D1478534569
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Initial antimicrobial management of sepsis.
Journal
Critical care
Author(s)
Niederman M.S., Baron R.M., Bouadma L., Calandra T., Daneman N., DeWaele J., Kollef M.H., Lipman J., Nair G.B.
ISSN
1466-609X (Electronic)
ISSN-L
1364-8535
Publication state
Published
Issued date
26/08/2021
Peer-reviewed
Oui
Volume
25
Number
1
Pages
307
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Sepsis is a common consequence of infection, associated with a mortality rate > 25%. Although community-acquired sepsis is more common, hospital-acquired infection is more lethal. The most common site of infection is the lung, followed by abdominal infection, catheter-associated blood steam infection and urinary tract infection. Gram-negative sepsis is more common than gram-positive infection, but sepsis can also be due to fungal and viral pathogens. To reduce mortality, it is necessary to give immediate, empiric, broad-spectrum therapy to those with severe sepsis and/or shock, but this approach can drive antimicrobial overuse and resistance and should be accompanied by a commitment to de-escalation and antimicrobial stewardship. Biomarkers such a procalcitonin can provide decision support for antibiotic use, and may identify patients with a low likelihood of infection, and in some settings, can guide duration of antibiotic therapy. Sepsis can involve drug-resistant pathogens, and this often necessitates consideration of newer antimicrobial agents.
Keywords
Antibiotic therapy, Antimicrobial therapy, Bacteremia, Biomarkers, Fungal infection, Intra-abdominal infection, Pharmacokinetics, Pneumonia, Sepsis
Pubmed
Web of science
Create date
10/09/2021 17:18
Last modification date
09/10/2021 5:39
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