Evidence for a role of sphingosine-1 phosphate in cardiovascular remodelling in Fabry disease.

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Serval ID
serval:BIB_0D07AF028847
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Evidence for a role of sphingosine-1 phosphate in cardiovascular remodelling in Fabry disease.
Journal
European Heart Journal
Author(s)
Brakch N., Dormond O., Bekri S., Golshayan D., Correvon M., Mazzolai L., Steinmann B., Barbey F.
ISSN
1522-9645[electronic], 0195-668X[linking]
Publication state
Published
Issued date
2010
Volume
31
Number
1
Pages
67-76
Language
english
Abstract
AIMS: A hallmark of Fabry disease is the concomitant development of left-ventricular hypertrophy and arterial intima-media thickening, the pathogenesis of which is thought to be related to the presence of a plasmatic circulating growth-promoting factor. We therefore characterized the plasma of patients with Fabry disease in order to identify this factor. METHODS AND RESULTS: Using a classical biochemical strategy, we isolated and identified sphingosine-1 phosphate (S1P) as a proliferative factor present in the plasma of patients with Fabry disease. Plasma S1P levels were significantly higher in 17 patients with Fabry disease compared with 17 healthy controls (225 +/- 40 vs. 164 +/- 17 ng/mL; P = 0.005). There was a positive correlation between plasma S1P levels and both common carotid artery intima-media thickness and left-ventricular mass index (r(2) = 0.47; P = 0.006 and r(2) = 0.53; P = 0.0007, respectively). In an experimental model, mice treated with S1P developed cardiovascular remodelling similar to that observed in patients with Fabry disease. CONCLUSION: Sphingosine-1 phosphate participates in cardiovascular remodelling in Fabry disease. Our findings have implications for the treatment of cardiovascular involvement in Fabry disease.
Pubmed
Web of science
Open Access
Yes
Create date
28/09/2009 14:35
Last modification date
25/09/2019 7:08
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