Repeated Pre-Syncope from Increased Inspired CO2 in a Background of Severe Hypoxia.

Details

Serval ID
serval:BIB_0CA733A4E441
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Repeated Pre-Syncope from Increased Inspired CO2 in a Background of Severe Hypoxia.
Journal
High Altitude Medicine and Biology
Author(s)
Fan J.L., Kayser B.
ISSN
1557-8682 (Electronic)
ISSN-L
1527-0297
Publication state
Published
Issued date
2014
Volume
15
Number
1
Pages
70-77
Language
english
Notes
Publication types: Journal Article , pdf : Case Reports
Abstract
We describe a case of experimentally induced pre-syncope in a healthy young man when exposed to increased inspired CO2 in a background of hypoxia. Acute severe hypoxia (FIO2=0.10) was tolerated, but adding CO2 to the inspirate caused pre-syncope symptoms accompanied by hypotension and large reductions in both mean and diastolic middle cerebral artery velocity, while systolic flow velocity was maintained. The mismatch of cerebral perfusion pressure and vascular tone caused unique retrograde cerebral blood flow at the end of systole and a reduction in cerebral tissue oxygenation. We speculate that this occurrence of pre-syncope was due to hypoxia-induced inhibition of brain regions responsible for compensatory sympathetic activity to relative hypercapnia.
Pubmed
Web of science
Create date
01/05/2014 18:47
Last modification date
20/08/2019 13:34
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