HIV-1 gp120 glycoprotein affects the astrocyte control of extracellular glutamate by both inhibiting the uptake and stimulating the release of the amino acid.

Details

Serval ID
serval:BIB_0C80EF5437D6
Type
Article: article from journal or magazin.
Collection
Publications
Title
HIV-1 gp120 glycoprotein affects the astrocyte control of extracellular glutamate by both inhibiting the uptake and stimulating the release of the amino acid.
Journal
FEBS Letters
Author(s)
Vesce S., Bezzi P., Rossi D., Meldolesi J., Volterra A.
ISSN
0014-5793 (Print)
ISSN-L
0014-5793
Publication state
Published
Issued date
1997
Volume
411
Number
1
Pages
107-109
Language
english
Abstract
The mechanisms of HIV-1 neurotoxicity remain still undefined although the induction of signalling events and a modest inhibition of glutamate uptake induced by the envelope glycoprotein, gp120, have called attention to astrocytes. Here we demonstrate that the levels at which the viral glycoprotein affects glutamate homeostasis of astrocyte cultures are at least two: not only the inhibition of uptake, due to an effect at site(s) away from the transporters of the amino acid but also a slow stimulation of release. The combination of these two events accounts for a considerable steady increase of the extracellular concentration of the excitatory amino acid which could play an important role in the neurotoxicity often observed in AIDS patients.
Keywords
Animals, Astrocytes/physiology, Cells, Cultured, Glutamic Acid/metabolism, Glutamic Acid/secretion, HIV Envelope Protein gp120/physiology, Kainic Acid/analogs & derivatives, Kainic Acid/pharmacology, Rats
Pubmed
Web of science
Create date
24/01/2008 15:37
Last modification date
20/08/2019 13:33
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