No interaction between alcohol consumption and HDL-related genes on HDL cholesterol levels.

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State: Public
Version: author
Serval ID
serval:BIB_0C76E908E3B0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
No interaction between alcohol consumption and HDL-related genes on HDL cholesterol levels.
Journal
Atherosclerosis
Author(s)
Marques-Vidal Pedro, Bochud Murielle, Paccaud Fred, Waterworth Dawn, Bergmann Sven, Preisig Martin, Waeber Gérard, Vollenweider Peter
ISSN
1879-1484[electronic]
ISSN-L
0021-9150[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
211
Number
1
Pages
551-557
Language
english
Abstract
OBJECTIVE: To assess the relationships and possible interactions between polymorphisms related to HDL levels and alcohol consumption. METHODS: Cross-sectional population-based study including 2863 women and 2546 men aged 35-75 years (CoLaus study). Alcohol intake was assessed by the reported alcohol consumption of the last 7 days. Nineteen candidate genes known to influence HDL levels were studied. RESULTS: Alcohol consumption increased HDL cholesterol levels in both genders. After multivariate adjustment for gender, age, body mass index, smoking, hypolipidaemic drug treatment, physical activity and alcohol consumption, APOA5, CETP, LIPC and LPL gene polymorphisms were significantly (10(-5) threshold) related with HDL cholesterol levels, while no genexalcohol intake interaction was found for all SNPs studied. ABCA1 polymorphisms were related to HDL cholesterol levels on bivariate analysis but the relationship was no longer significant after multivariate analysis. CONCLUSION: Our data confirm the association of alcohol consumption and of APOA5, CETP, LIPC and LPL gene polymorphisms with HDL cholesterol levels. Conversely, no genexalcohol consumption interactions were found, suggesting that the effect of alcohol consumption on HDL cholesterol levels is not mediated via a modulation of HDL related genes.
Keywords
Colaus Study , ATP-Binding Cassette Transporters/genetics , Adult , Aged , Alcohol Drinking* , Cholesterol, HDL/blood* , Cross-Sectional Studies , Female , Gene Expression Regulation* , Humans , Lipoprotein Lipase/genetics , Male , Middle Aged , Multivariate Analysis , Polymorphism, Genetic* , Sex Factors
Pubmed
Web of science
Create date
07/05/2010 17:00
Last modification date
25/11/2019 8:08
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