Serum IGF-I and C-reactive protein in healthy black and white young men: the CARDIA male hormone study.

Details

Serval ID
serval:BIB_0C0CFFF504E3
Type
Article: article from journal or magazin.
Collection
Publications
Title
Serum IGF-I and C-reactive protein in healthy black and white young men: the CARDIA male hormone study.
Journal
Growth hormone & IGF research
Author(s)
Colangelo L.A., Chiu B., Kopp P., Liu K., Gapstur S.M.
ISSN
1532-2238 (Electronic)
ISSN-L
1096-6374
Publication state
Published
Issued date
10/2009
Peer-reviewed
Oui
Volume
19
Number
5
Pages
420-425
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural
Publication Status: ppublish
Abstract
Animal and human studies suggest that C-reactive protein (CRP) may be inversely associated with serum insulin-like growth factor-I (IGF-I) concentrations. However, most human studies have not controlled adequately for confounding factors, particularly nutritional intake. This population-based study examined whether CRP is inversely associated with IGF-I and IGFBP-3 concentrations.
In cross-sectional analysis, multivariable linear regression with adjustment for age, BMI, smoking status, alcohol intake, and nutritional factors was used to relate log CRP, the independent variable, to IGF-I and IGFBP-3 in a sample of black (n=364) and white men (n=486) separately by race.
Only black men had positive findings: log CRP was significantly associated with IGF-I (beta=-13.1 ng/ml, p=0.02) and the difference in mean IGF-I concentrations between the highest and lowest quartiles of CRP was 26 ng/ml. There was a statistically significant interaction between log CRP and smoking status (p=0.02); the regression coefficient for IGF-I predicted from log CRP was significant in smokers (beta=-39.8 ng/ml, p=0.0001), but not in non-smokers. The difference in mean IGF-I concentrations between highest and lowest quartiles of CRP was 100 ng/ml for black smokers. There were no associations for IGFBP-3.
In our study, CRP levels are inversely associated with IGF-I concentrations in black male smokers; however, the causal nature of the association is unclear and should be studied further.
Keywords
Adult, African Americans, C-Reactive Protein/metabolism, Cross-Sectional Studies, European Continental Ancestry Group, Humans, Insulin-Like Growth Factor Binding Protein 3, Insulin-Like Growth Factor Binding Proteins/blood, Insulin-Like Growth Factor I/metabolism, Male
Pubmed
Web of science
Create date
30/12/2020 14:01
Last modification date
31/12/2020 6:26
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