Transient structural variations have strong effects on quantitative traits and reproductive isolation in fission yeast.

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State: Public
Version: Final published version
Serval ID
serval:BIB_0B9096E627F3
Type
Article: article from journal or magazin.
Collection
Publications
Title
Transient structural variations have strong effects on quantitative traits and reproductive isolation in fission yeast.
Journal
Nature communications
Author(s)
Jeffares D.C., Jolly C., Hoti M., Speed D., Shaw L., Rallis C., Balloux F., Dessimoz C., Bähler J., Sedlazeck F.J.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
24/01/2017
Peer-reviewed
Oui
Volume
8
Pages
14061
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Large structural variations (SVs) within genomes are more challenging to identify than smaller genetic variants but may substantially contribute to phenotypic diversity and evolution. We analyse the effects of SVs on gene expression, quantitative traits and intrinsic reproductive isolation in the yeast Schizosaccharomyces pombe. We establish a high-quality curated catalogue of SVs in the genomes of a worldwide library of S. pombe strains, including duplications, deletions, inversions and translocations. We show that copy number variants (CNVs) show a variety of genetic signals consistent with rapid turnover. These transient CNVs produce stoichiometric effects on gene expression both within and outside the duplicated regions. CNVs make substantial contributions to quantitative traits, most notably intracellular amino acid concentrations, growth under stress and sugar utilization in winemaking, whereas rearrangements are strongly associated with reproductive isolation. Collectively, these findings have broad implications for evolution and for our understanding of quantitative traits including complex human diseases.
Keywords
Chromosome Inversion/genetics, Chromosomes, Fungal/genetics, DNA Copy Number Variations/genetics, Evolution, Molecular, Gene Expression Regulation, Fungal, Genome, Fungal/genetics, Quantitative Trait, Heritable, Reproductive Isolation, Schizosaccharomyces/genetics, Translocation, Genetic/genetics
Pubmed
Web of science
Open Access
Yes
Create date
30/01/2017 19:54
Last modification date
20/08/2019 13:33
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