Modeling knee osteoarthritis pathophysiology using an integrated joint system (IJS): a systematic review of relationships among cartilage thickness, gait mechanics, and subchondral bone mineral density.

Details

Serval ID
serval:BIB_0B659BC46A32
Type
Article: article from journal or magazin.
Collection
Publications
Title
Modeling knee osteoarthritis pathophysiology using an integrated joint system (IJS): a systematic review of relationships among cartilage thickness, gait mechanics, and subchondral bone mineral density.
Journal
Osteoarthritis and cartilage
Author(s)
Edd S.N., Omoumi P., Andriacchi T.P., Jolles B.M., Favre J.
ISSN
1522-9653 (Electronic)
ISSN-L
1063-4584
Publication state
Published
Issued date
11/2018
Peer-reviewed
Oui
Volume
26
Number
11
Pages
1425-1437
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
To introduce an integrated joint system (IJS) model of joint health and osteoarthritis (OA) pathophysiology through a systematic review of the cross-sectional relationships among three knee properties (cartilage thickness, gait mechanics, and subchondral bone mineral density).
Searches using keywords associated with the three knee properties of interest were performed in PubMed, Scopus, and Ovid databases. English-language articles reporting cross-sectional correlations between at least two knee properties in healthy or tibiofemoral OA human knees were included. A narrative synthesis of the data was conducted.
Of the 5600 retrieved articles, 13 were included, eight of which reported relationships between cartilage thickness and gait mechanics. The 744 tested knees were separated into three categories based on knee health: 199 healthy, 340 at-risk/early OA, and 205 late OA knees. Correlations between knee adduction moment and medial-to-lateral cartilage thickness ratios were generally positive in healthy, inconclusive in at-risk/early OA, and negative in late OA knees. Knee adduction moment was positively correlated with medial-to-lateral tibial subchondral bone mineral density ratios in knees of all health categories. One study reported a positive correlation between lateral tibial subchondral bone mineral density and femoral cartilage thickness in at-risk/early OA knees.
The correlations identified between knee properties in this review agreed with the proposed relationship-based IJS model of OA pathophysiology. Accordingly, the IJS model could provide insights into overcoming current barriers to developing disease-modifying treatments by considering multiple aspects of OA disease, aspects that could be assessed simultaneously at an in vivo system level.
Keywords
Cartilage thickness, Gait mechanics, Knee osteoarthritis, Subchondral bone mineral density
Pubmed
Web of science
Create date
07/08/2018 10:49
Last modification date
20/08/2019 13:33
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