Interindividual differences in the binding of antidepressives to plasma proteins: the role of the variants of alpha 1-acid glycoprotein

Details

Serval ID
serval:BIB_0B552A72437C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Interindividual differences in the binding of antidepressives to plasma proteins: the role of the variants of alpha 1-acid glycoprotein
Journal
Eur J Clin Pharmacol
Author(s)
Tinguely Dominique, Baumann Pierre, Conti Maria, Jonzier-Perey Michèle, Schopf Josef
ISSN
0031-6970 (Print)
ISSN-L
0031-6970
Publication state
Published
Issued date
1985
Volume
27
Number
6
Pages
661-6
Language
english
Notes
Tinguely, D
Baumann, P
Conti, M
Jonzier-Perey, M
Schopf, J
eng
Research Support, Non-U.S. Gov't
Germany
Eur J Clin Pharmacol. 1985;27(6):661-6. doi: 10.1007/BF00547045.
Abstract
Alpha 1-acid glycoprotein (AAG) is one of the plasma proteins that bind basic drugs, like amitriptyline (AT) and its metabolite nortriptyline (NT). Two types of genetic polymorphism have been described for AAG: polymorphic forms which, on electrophoresis of the native protein, give four patterns with 5, 6, 7 or 8 bands, and the variants which on by electrophoresis of the desialysed protein, give three patterns with 2 bands, FF, FS and SS. In 31 depressive patients, treated daily with 150 mg AT for 3 weeks, free and total plasma AT and NT were determined, as well as the AAG polymorphic forms and variants. There was only a weak negative correlation between the free fractions of AT and NT and total plasma AAG, but free AT and NT were strongly correlated with the S form (but not the F form) of AAG variants. The differences in binding might be the expression of a further genetic factor determining the steady-state plasma levels of tricyclic drugs.
Keywords
Adult, Amitriptyline/blood, Antidepressive Agents/blood/*metabolism, Blood Proteins/*metabolism, Depressive Disorder/blood, Female, Humans, Male, Middle Aged, Nortriptyline/blood, Orosomucoid/genetics/*metabolism, Polymorphism, Genetic, Protein Binding, Time Factors
Pubmed
Create date
11/01/2021 11:35
Last modification date
22/01/2021 6:26
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