Extended intermarker linkage disequilibrium in the Afrikaners.

Details

Serval ID
serval:BIB_0B474EF22857
Type
Article: article from journal or magazin.
Collection
Publications
Title
Extended intermarker linkage disequilibrium in the Afrikaners.
Journal
Genome Research
Author(s)
Hall D., Wijsman E.M., Roos J.L., Gogos J.A., Karayiorgou M.
ISSN
1088-9051 (Print)
ISSN-L
1088-9051
Publication state
Published
Issued date
2002
Volume
12
Number
6
Pages
956-961
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Abstract
In this study we conducted an investigation of the background level of linkage disequilibrium (LD) in the Afrikaner population to evaluate the appropriateness of this genetic isolate for mapping complex traits. We analyzed intermarker LD in 62 nuclear families using microsatellite markers covering extended chromosomal regions. The markers were selected to allow the first direct comparison of long-range LD in the Afrikaners to LD in other demographic groups. Using several statistical measures, we find significant evidence for LD in the Afrikaners extending remarkably over a 6-cM range. In contrast, LD decays significantly beyond 3-cM distances in the other founder and outbred populations examined. This study strongly supports the appropriateness of the Afrikaner population for genome-wide scans that exploit LD to map common, multigenic disorders.
Keywords
Chromosome Mapping, Chromosomes, Human, Pair 18/genetics, Ethnic Groups/genetics, European Continental Ancestry Group/genetics, Genetic Markers/genetics, Genetics, Population, Humans, Linkage Disequilibrium/genetics, Microsatellite Repeats/genetics, Netherlands, South Africa
Pubmed
Open Access
Yes
Create date
27/02/2012 16:46
Last modification date
20/08/2019 12:33
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