Molecular physiology of glucose transporters.

Details

Serval ID
serval:BIB_0B1D27EB92A7
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Molecular physiology of glucose transporters.
Journal
Diabetes Care
Author(s)
Thorens B., Charron M.J., Lodish H.F.
ISSN
0149-5992[print], 0149-5992[linking]
Publication state
Published
Issued date
03/1990
Volume
13
Number
3
Pages
209-218
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
Publication Status: ppublish
Abstract
Molecular cloning of cDNA encoding the human erythrocyte facilitated-diffusion glucose transporter (GT) has elucidated its structure and has permitted a careful study of its tissue distribution and of its involvement in processes such as insulin-stimulated glucose uptake by adipose cells or transformation-induced increase in glucose metabolism. An important outcome of these studies was the discovery that additional isoforms of this transporter were expressed in a tissue-specific manner; these comprise a family of structurally and functionally related molecules. Their tissue distribution, differences in kinetic properties, and differential regulation by ambient glucose and insulin levels suggest that they play specific roles in the control of glucose homeostasis. Herein, we will discuss the structure of three members of the GT family: erythroid/brain GT, liver GT, and adipose cell/muscle GT. In the light of their tissue-specific expression, kinetic parameters, and susceptibility to insulin action, we discuss their possible specific functions.
Keywords
Amino Acid Sequence, Animals, Cell Membrane/metabolism, Cloning, Molecular, Humans, Models, Molecular, Molecular Sequence Data, Monosaccharide Transport Proteins/genetics, Monosaccharide Transport Proteins/physiology, Organ Specificity, Protein Conformation, Sequence Homology, Nucleic Acid
Pubmed
Web of science
Create date
24/01/2008 13:41
Last modification date
20/08/2019 12:32
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