SPHN - The Swiss Aging Citizen Reference (SACR).

Details

Serval ID
serval:BIB_0ADE64479CBB
Type
Article: article from journal or magazin.
Publication sub-type
Editorial
Collection
Publications
Institution
Title
SPHN - The Swiss Aging Citizen Reference (SACR).
Journal
Studies in health technology and informatics
Author(s)
Jeong A., Bochud M., Cattin P., Dermitzakis M., Draganski B., Papassotiropoulos A., Preisig M., Stieltjes B., Vollenweider P., Probst-Hensch N.
ISSN
1879-8365 (Electronic)
ISSN-L
0926-9630
Publication state
Published
Issued date
16/06/2020
Peer-reviewed
Oui
Volume
270
Pages
1168-1169
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
In Switzerland by 2045, we expect 2.7 Mio citizens aged 65+ of whom 1.0 Mio. aged 80+. A priority and focus of personalized health research is therefore aging biology to extend healthy life expectancy. Novel molecular and imaging features will emerge as candidate targets for risk prediction and screening of chronic diseases. It is of utmost importance to test the clinical and public health utility of candidate biomarkers evolving from this research in citizen reference cohorts. We will build a Swiss Aging Citizen Reference (SACR), a testable and scalable reference cohort offering interoperable, searchable, and accessible data. 1000 participants from existing Swiss citizen cohorts will be combined and analyzed for DNA methylation and MRI brain imaging. SACR will serve as a testbed for clinical and public health utility of candidate biomarkers. As for a proof-of-concept study, we will conduct an agnostic search for structural and functional brain features associated with epigenetic aging acceleration to examine the potential of epigenetic age acceleration as the intermediate aging biomarker and to better understand the aging mechanism in brain.
Keywords
DNA methylation, SPHN, aging, brain imaging, citizen reference, personalized health
Pubmed
Create date
03/07/2020 18:31
Last modification date
20/01/2021 6:26
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