Innate Immune Cells and Their Contribution to T-Cell-Based Immunotherapy.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_0AC8DC8B4A8A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Innate Immune Cells and Their Contribution to T-Cell-Based Immunotherapy.
Journal
International journal of molecular sciences
Author(s)
Ginefra P., Lorusso G., Vannini N.
ISSN
1422-0067 (Electronic)
ISSN-L
1422-0067
Publication state
Published
Issued date
22/06/2020
Peer-reviewed
Oui
Volume
21
Number
12
Pages
4441
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
In recent years, immunotherapy has become the most promising therapy for a variety of cancer types. The development of immune checkpoint blockade (ICB) therapies, the adoptive transfer of tumor-specific T cells (adoptive cell therapy (ACT)) or the generation of T cells engineered with chimeric antigen receptors (CAR) have been successfully applied to elicit durable immunological responses in cancer patients. However, not all the patients respond to these therapies, leaving a consistent gap of therapeutic improvement that still needs to be filled. The innate immune components of the tumor microenvironment play a pivotal role in the activation and modulation of the adaptive immune response against the tumor. Indeed, several efforts are made to develop strategies aimed to harness innate immune cells in the context of cancer immunotherapy. In this review, we describe the contribution of innate immune cells in T-cell-based cancer immunotherapy and the therapeutic approaches implemented to broaden the efficacy of these therapies in cancer patients.
Keywords
Animals, Humans, Immunity, Innate/immunology, Immunotherapy/methods, Immunotherapy, Adoptive/methods, Neoplasms/immunology, Neoplasms/therapy, Tumor Microenvironment/immunology, adaptive immunity, immunotherapy, immunotolerance, innate immunity, myeloid cells
Pubmed
Web of science
Open Access
Yes
Create date
03/07/2020 18:44
Last modification date
03/04/2021 6:31
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