Determinants of hepatitis A vaccine immunity in a cohort of human immunodeficiency virus-infected children living in Switzerland.

Details

Serval ID
serval:BIB_0AC3C5702980
Type
Article: article from journal or magazin.
Collection
Publications
Title
Determinants of hepatitis A vaccine immunity in a cohort of human immunodeficiency virus-infected children living in Switzerland.
Journal
Clinical and Vaccine Immunology
Author(s)
Crisinel P.A., Posfay-Barbe K.M., Aebi C., Cheseaux J.J., Kahlert C., Rudin C., Nadal D., Siegrist C.A.
Working group(s)
Swiss Mother, Child HIV Cohort Study of Switzerland
Contributor(s)
Aebi C., Battegay M., Bernasconi E., Böni J., Brazzola P., Bucher HC., Bürgisser P., Calmy A., Cattacin S., Cavassini M., Cheseaux JJ., Drack G., Dubs R., Egger M., Elzi L., Fischer M., Flepp M., Fontana A., Francioli P., Furrer H., Fux CA., Gayet-Ageron A., Gerber S., Gorgievski M., Grawe C., Günthard HF., Gyr T., Hirsch HH., Hirschel B., Hösli I., Kaiser L., Kahlert C., Karrer U., Kind C., Klimkait T., Ledergerber B., Martinetti G., Müller N., Nadal D., Paccaud F., Pantaleo G., Raio L., Rauch A., Regenass S., Rickenbach M., Rudin C., Schmid P., Schultze D., Schöni-Affolter F., Schüpbach J., Speck R., de Tejada BM. , Taffé P., Telenti A., Trkola A., Vernazza P., Weber R., Wyler CA., Yerly S.
ISSN
1556-679X (Electronic)
ISSN-L
1556-679X
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
19
Number
11
Pages
1751-1757
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Vaccination in HIV-infected children is often less effective than in healthy children. The goal of this study was to assess vaccine responses to hepatitis A virus (HAV) in HIV-infected children. Children of the Swiss Mother and Child HIV Cohort Study (MoCHiV) were enrolled prospectively. Recommendations for initial, catch-up, and additional HAV immunizations were based upon baseline antibody concentrations and vaccine history. HAV IgG was assessed by enzyme-linked immunosorbent assay (ELISA) with a protective cutoff value defined as ≥10 mIU/ml. Eighty-seven patients were included (median age, 11 years; range, 3.4 to 21.2 years). Forty-two patients were seropositive (48.3%) for HAV. Among 45 (51.7%) seronegative patients, 36 had not received any HAV vaccine dose and were considered naïve. Vaccine responses were assessed after the first dose in 29/35 naïve patients and after the second dose in 33/39 children (25 initially naïve patients, 4 seronegative patients, and 4 seropositive patients that had already received 1 dose of vaccine). Seroconversion was 86% after 1 dose and 97% after 2 doses, with a geometric mean concentration of 962 mIU/ml after the second dose. A baseline CD4(+) T cell count below 750 cells/μl significantly reduced the post-2nd-dose response (P = 0.005). Despite a high rate of seroconversion, patients with CD4(+) T cell counts of <750/μl had lower anti-HAV antibody concentrations. This may translate into a shorter protection time. Hence, monitoring humoral immunity may be necessary to provide supplementary doses as needed.
Keywords
Adolescent, CD4 Lymphocyte Count, Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Female, HIV Infections/immunology, Hepatitis A/prevention & control, Hepatitis A Antibodies/blood, Hepatitis A Vaccines/administration & dosage, Hepatitis A Vaccines/immunology, Humans, Immunoglobulin G/blood, Male, Prospective Studies, Switzerland, Vaccination/methods, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
06/12/2012 19:51
Last modification date
08/05/2019 14:13
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